Microfluidics pp 153-169 | Cite as

A Nanomembrane-Based Nucleic Acid Sensing Platform for Portable Diagnostics

  • Satyajyoti Senapati
  • Sagnik Basuray
  • Zdenek Slouka
  • Li-Jing Cheng
  • Hsueh-Chia ChangEmail author
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 304)


In this perspective article, we introduce a potentially transformative DNA/RNA detection technology that promises to replace DNA microarray and real-time PCR for field applications. It represents a new microfluidic technology that fully exploits the small spatial dimensions of a biochip and some new phenomena unique to the micro- and nanoscales. More specifically, it satisfies all the requisites for portable on-field applications: fast, small, sensitive, selective, robust, label- and reagent-free, economical to produce, and possibly PCR-free. We discuss the mechanisms behind the technology and introduce some preliminary designs, test results, and prototypes.


Depletion Dielectrophoresis Ion-selective membranes Limiting-current 



Alternating current


Carbon nanotube


Direct current




Deoxyribonucleic acid


Fluorescence correlation spectroscopy


Field-effect transistor






Polymerase chain reaction




Ribonucleic acid


Single-nucleotide polymorphism


Single-stranded DNA



The authors are grateful to NSF, Great Lakes Protection Agency, Gates Foundation, NIH and ND-PDT for their generous support of this research.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Satyajyoti Senapati
    • 1
  • Sagnik Basuray
    • 1
  • Zdenek Slouka
    • 1
  • Li-Jing Cheng
    • 1
  • Hsueh-Chia Chang
    • 1
    Email author
  1. 1.Department of Chemical and Biomolecular EngineeringUniversity of Notre DameNotre DameUSA

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