Abstract
Medical device-associated infections, most frequently caused by Staphylococcus epidermidis and Staphylococcus aureus, are of increasing importance in modern medicine. The formation of adherent, multilayered bacterial biofilms is crucial in the pathogenesis of these infections. Polysaccharide intercellular adhesin (PIA), a homoglycan of β-1,6-linked 2-acetamido-2-deoxy-d-glucopyranosyl residues, of which about 15% are non-N-acetylated, is central to biofilm accumulation in staphylococci. It transpires that polysaccharides – structurally very similar to PIA – are also key to biofilm formation in a number of other organisms including the important human pathogens Escherichia coli, Aggregatibacter (Actinobacillus) actinomycetemcomitans, Yersinia pestis, and Bordetella spp. Apparently, synthesis of PIA and related polysaccharides is a general feature important for biofilm formation in diverse bacterial genera. Current knowledge about the structure and biosynthesis of PIA and related polysaccharides is reviewed. Additionally, information on their role in pathogenesis of biomaterial-related and other type of infections and the potential use of PIA and related compounds for prevention of infection is evaluated.
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References
Hall-Stoodley L, Costerton JW, Stoodley P (2004) Nat Rev Microbiol 2:95
Mack D, Horstkotte MA, Rohde H, Knobloch JKM (2006) Coagulase-negative staphylococci. In: Pace JL, Rupp ME, Finch RG (eds) Biofilms, infection, and antimicrobial therapy. CRC, Boca Raton, p 109chap 7,
Lowy FD (1998) N Engl J Med 339:520
Foster TJ (2005) Nat Rev Microbiol 3:948
Rupp ME, Archer GL (1994) Clin Infect Dis 19:231
U.S.Department of Health and Human Services (1996) Am J Infect Control 24:380
Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB (2004) Clin Infect Dis 39:309
Mack D, Rohde H, Harris LG, Davies AP, Horstkotte MA, Knobloch JKM (2006) Int J Artif Organs 29:343
Otto M (2004) Front Biosci 9:841
Götz F (2002) Mol Microbiol 43:1367
Costerton JW, Stewart PS, Greenberg EP (1999) Science 284:1318
Harris LG, Richards RG (2004) J Mater Sci Mater Med 15:311
Rohde H, Mack D, Christner M, Burdelski C, Franke G, Knobloch JKM (2006) Rev Med Microbiol 17:45
Lewis K (2007) Nat Rev Microbiol 5:48
Nilsson M, Frykberg L, Flock JI, Pei L, Lindberg M, Guss B (1998) Infect Immun 66:2666
Hartford O, O’Brien L, Schofield K, Wells J, Foster TJ (2001) Microbiology 147:2545
Williams RJ, Henderson B, Sharp LJ, Nair SP (2002) Infect Immun 70:6805
Timmerman CP, Fleer A, Besnier JM, De Graaf L, Cremers F, Verhoef J (1991) Infect Immun 59:4187
Veenstra GJ, Cremers FF, van Dijk H, Fleer A (1996) J Bacteriol 178:537
Vaudaux PE, Lew DP, Waldvogel FA (1994) Host factors predeposing to and influencing therapy of foreign body infections. In: Bisno AL, Waldvogel FA (eds.) Infections associated with indwelling medical devices. American Society for Microbiology, Washington DC, p 1chap 1,
Mack D, Bartscht K, Dobinsky S, Horstkotte MA, Kiel K, Knobloch JKM, Schäfer P (2000) Staphylococcal factors involved in adhesion and biofilm formation on biomaterials. In: An YH, Friedman RJ (eds.) Handbook for studying bacterial adhesion: principles, methods, and applications. Humana Press, Totowa, N J, p 307chap 20,
Espersen F, Wilkinson BJ, Gahrn-Hansen B, Thamdrup RV, Clemmensen I (1990) APMIS 98:471
Hogt AH, Dankert J, Feijen J (1985) J Gen Microbiol 131:2485
Hogt AH, Dankert J, Feijen J (1986) J Biomed Mater Res 20:533
Hogt AH, Dankert J, Hulstaert CE, Feijen J (1986) Infect Immun 51:294
Pascual A, Fleer A, Westerdaal NA, Verhoef J (1986) Eur J Clin Microbiol Infect Dis 5:518
Muller E, Takeda S, Shiro H, Goldmann D, Pier GB (1993) J Infect Dis 168:1211
Ludwicka A, Jansen B, Wadstrom T, Pulverer G (1984) Zentralbl Bakteriol Mikrobiol Hyg A 256:479
Mack D, Bartscht K, Fischer C, Rohde H, de Grahl C, Dobinsky S, Horstkotte MA, Kiel K, Knobloch JKM (2001) Methods Enzymol 336:215
Patel JD, Ebert M, Ward R, Anderson JM (2007) J Biomed Mater Res A 80:742
Heilmann C, Schweitzer O, Gerke C, Vanittanakom N, Mack D, Götz F (1996) Mol Microbiol 20:1083
Heilmann C, Hussain M, Peters G, Götz F (1997) Mol Microbiol 24:1013
Rupp ME, Fey PD, Heilmann C, Götz F (2001) J Infect Dis 183:1038
Li DQ, Lundberg F, Ljungh A (2001) Curr Microbiol 42:361
Tojo M, Yamashita N, Goldmann DA, Pier GB (1988) J Infect Dis 157:713
Higashi JM, Wang IW, Shlaes DM, Anderson JM, Marchant RE (1998) J Biomed Mater Res 39:341
McKenney D, Hübner J, Muller E, Wang Y, Goldmann DA, Pier GB (1998) Infect Immun 66:4711
Joyce JG, Abeygunawardana C, Xu Q, Cook JC, Hepler R, Przysiecki CT, Grimm KM, Roper K, Ip CC, Cope L, Montgomery D, Chang M, Campie S, Brown M, McNeely TB, Zorman J, Maira-Litran T, Pier GB, Keller PM, Jansen KU, Mark GE (2003) Carbohydr Res 338:903
Maira-Litran T, Kropec A, Abeygunawardana C, Joyce J, Mark IG, Goldmann DA, Pier GB (2002) Infect Immun 70:4433
Mack D, Fischer W, Krokotsch A, Leopold K, Hartmann R, Egge H, Laufs R (1996) J Bacteriol 178:175
Maira-Litran T, Kropec A, Goldmann D, Pier GB (2004) Vaccine 22:872
Sadovskaya I, Vinogradov E, Flahaut S, Kogan G, Jabbouri S (2005) Infect Immun 73:3007
Whitchurch CB, Tolker-Nielsen T, Ragas PC, Mattick JS (2002) Science 295:1487
Eckhart L, Fischer H, Barken KB, Tolker-Nielsen T, Tschachler E (2007) Br J Dermatol 156:1342
Izano EA, Amarante MA, Kher WB, Kaplan JB (2008) Appl Environ Microbiol 74:470
Rice KC, Mann EE, Endres JL, Weiss EC, Cassat JE, Smeltzer MS, Bayles KW (2007) Proc Natl Acad Sci U S A 104:8113
Qin Z, Ou Y, Yang L, Zhu Y, Tolker-Nielsen T, Molin S, Qu D (2007) Microbiology 153:2083
Heilmann C, Gerke C, Perdreau-Remington F, Götz F (1996) Infect Immun 64:277
Patti JM, Allen BL, McGavin MJ, Höök M (1994) Annu Rev Microbiol 48:585
Heilmann C, Thumm G, Chhatwal GS, Hartleib J, Uekotter A, Peters G (2003) Microbiology 149:2769
Rohde H, Kalitzky M, Kröger N, Scherpe S, Horstkotte MA, Knobloch JKM, Zander AR, Mack D (2004) J Clin Microbiol 42:5614
Rohde H, Burandt EC, Siemssen N, Frommelt L, Burdelski C, Wurster S, Scherpe S, Davies AP, Harris LG, Horstkotte MA, Knobloch JK, Ragunath C, Kaplan JB, Mack D (2007) Biomaterials 28:1711
Arciola CR, Campoccia D, Gamberini S, Donati ME, Montanaro L (2004) Biomaterials 25:4825
Pei L, Flock JI (2001) J Infect Dis 184:52
Rennermalm A, Nilsson M, Flock JI (2004) Infect Immun 72:3081
Vernachio JH, Bayer AS, Ames B, Bryant D, Prater BD, Syribeys PJ, Gorovits EL, Patti JM (2006) Antimicrob Agents Chemother 50:511
Hussain M, Heilmann C, Peters G, Herrmann M (2001) Microb Pathog 31:261
Bustanji Y, Arciola CR, Conti M, Mandello E, Montanaro L, Samori B (2003) Proc Natl Acad Sci U S A 100:13292
Bowden MG, Visai L, Longshaw CM, Holland KT, Speziale P, Höök M (2002) J Biol Chem 277:43017
Mack D, Siemssen N, Laufs R (1992) Infect Immun 60:2048
Mack D, Nedelmann M, Krokotsch A, Schwarzkopf A, Heesemann J, Laufs R (1994) Infect Immun 62:3244
Mack D, Haeder M, Siemssen N, Laufs R (1996) J Infect Dis 174:881
Ziebuhr W, Heilmann C, Götz F, Meyer P, Wilms K, Straube E, Hacker J (1997) Infect Immun 65:890
Cramton SE, Gerke C, Schnell NF, Nichols WW, Götz F (1999) Infect Immun 67:5427
McKenney D, Pouliot KL, Wang Y, Murthy V, Ulrich M, Doring G, Lee JC, Goldmann DA, Pier GB (1999) Science 284:1523
Tu Quoc PH, Genevaux P, Pajunen M, Savilahti H, Georgopoulos C, Schrenzel J, Kelley WL (2007) Infect Immun 75:1079
Chokr A, Watier D, Eleaume H, Pangon B, Ghnassia JC, Mack D, Jabbouri S (2006) Int J Med Microbiol 296:381
Hennig S, Nyunt WS, Ziebuhr W (2007) Int J Med Microbiol 297:117
Hussain M, Herrmann M, von Eiff C, Perdreau-Remington F, Peters G (1997) Infect Immun 65:519
Rohde H, Burdelski C, Bartscht K, Hussain M, Buck F, Horstkotte MA, Knobloch JKM, Heilmann C, Herrmann M, Mack D (2005) Mol Microbiol 55:1883
Banner MA, Cunniffe JG, Macintosh RL, Foster TJ, Rohde H, Mack D, Hoyes E, Derrick J, Upton M, Handley PS (2007) J Bacteriol 189:2793
Corrigan RM, Rigby D, Handley P, Foster TJ (2007) Microbiology 153:2435
Fitzpatrick F, Humphreys H, O’Gara JP (2005) J Clin Microbiol 43:1973
O’Neill E, Pozzi C, Houston P, Humphreys H, Robinson DA, Loughman A, Foster TJ, O’Gara JP (2008) J Bacteriol 190:3835
Gerke C, Kraft A, Süssmuth R, Schweitzer O, Götz F (1998) J Biol Chem 273:18586
Allignet J, Aubert S, Dyke KG, El Solh N (2001) Infect Immun 69:712
Frank KL, Patel R (2007) Infect Immun 75:4728
Moretro T, Hermansen L, Holck AL, Sidhu MS, Rudi K, Langsrud S (2003) Appl Environ Microbiol 69:5648
Wang X, Preston JF III, Romeo T (2004) J Bacteriol 186:2724
Kaplan JB, Velliyagounder K, Ragunath C, Rohde H, Mack D, Knobloch JKM, Ramasubbu N (2004) J Bacteriol 186:8213
Izano EA, Sadovskaya I, Vinogradov E, Mulks MH, Velliyagounder K, Ragunath C, Kher WB, Ramasubbu N, Jabbouri S, Perry MB, Kaplan JB (2007) Microb Pathog 43:1
Parise G, Mishra M, Itoh Y, Romeo T, Deora R (2007) J Bacteriol 189:750
Sloan GP, Love CF, Sukumar N, Mishra M, Deora R (2007) J Bacteriol 189:8270
Darby C, Hsu JW, Ghori N, Falkow S (2002) Nature 417:243
Itoh Y, Wang X, Hinnebusch BJ, Preston JF III, Romeo T (2005) J Bacteriol 187:382
Bobrov AG, Kirillina O, Forman S, Mack D, Perry RD (2008) Environ Microbiol 10:1419
Drewry DT, Galbraith L, Wilkinson BJ, Wilkinson SG (1990) J Clin Microbiol 28:1292
Mack D (1999) J Hosp Infect 43:(Suppl)S113
Rupp ME, Archer GL (1992) Infect Immun 60:4322
Mack D, Riedewald J, Rohde H, Magnus T, Feucht HH, Elsner HA, Laufs R, Rupp ME (1999) Infect Immun 67:1004
Fey PD, Ulphani JS, Götz F, Heilmann C, Mack D, Rupp ME (1999) J Infect Dis 179:1561
Samek O, Telle HH, Harris LG, Bloomfield M, Mack D (2008) Laser Phys Lett 5:465
Jefferson KK, Cramton SE, Götz F, Pier GB (2003) Mol Microbiol 48:889
Goller C, Wang X, Itoh Y, Romeo T (2006) J Bacteriol 188:8022
Itoh Y, Rice JD, Goller C, Pannuri A, Taylor J, Meisner J, Beveridge TJ, Preston JF III, Romeo T (2008) J Bacteriol 190:3670
Kaplan JB, Ragunath C, Ramasubbu N, Fine DH (2003) J Bacteriol 185:4693
Kaplan JB, Ragunath C, Velliyagounder K, Fine DH, Ramasubbu N (2004) Antimicrob Agents Chemother 48:2633
Izano EA, Sadovskaya I, Wang H, Vinogradov E, Ragunath C, Ramasubbu N, Jabbouri S, Perry MB, Kaplan JB (2008) Microb Pathog 44:52
Maira-Litran T, Kropec A, Goldmann DA, Pier GB (2005) Infect Immun 73:6752
Ziebuhr W, Krimmer V, Rachid S, Lößner I, Götz F, Hacker J (1999) Mol Microbiol 32:345
Wang C, Li M, Dong D, Wang J, Ren J, Otto M, Gao Q (2007) Microbes Infect 9:1376
Wang L, Li M, Dong D, Bach TH, Sturdevant DE, Vuong C, Otto M, Gao Q (2008) J Infect Dis 197:1254
Knobloch JKM, Bartscht K, Sabottke A, Rohde H, Feucht HH, Mack D (2001) J Bacteriol 183:2624
Knobloch JKM, Jäger S, Horstkotte MA, Rohde H, Mack D (2004) Infect Immun 72:3838
Conlon KM, Humphreys H, O’Gara JP (2002) J Bacteriol 184:4400
Conlon KM, Humphreys H, O’Gara JP (2004) J Bacteriol 186:6208
Tormo MA, Marti M, Valle J, Manna AC, Cheung AL, Lasa I, Penades JR (2005) J Bacteriol 187:2348
Xu L, Li H, Vuong C, Vadyvaloo V, Wang J, Yao Y, Otto M, Gao Q (2006) Infect Immun 74:488
Jefferson KK, Pier DB, Goldmann DA, Pier GB (2004) J Bacteriol 186:2449
Frank KL, Luis DP, Patel R (2008) Clin Microbiol Rev 21:111
Knobloch JK, Horstkotte MA, Rohde H, Mack D (2002) Med Microbiol Immunol 191:101
Mack D, Becker P, Chatterjee I, Knobloch JKM, Peters G, Rohde H, Herrmann M (2004) Int J Med Microbiol 294:203
Kong KF, Vuong C, Otto M (2006) Int J Med Microbiol 296:133
Mack D, Davies AP, Harris LG, Rohde H, Horstkotte MA, Knobloch JK (2007) Anal Bioanal Chem 387:399
O’Gara JP (2007) FEMS Microbiol Lett 270:179
Gill SR, Fouts DE, Archer GL, Mongodin EF, Deboy RT, Ravel J, Paulsen IT, Kolonay JF, Brinkac L, Beanan M, Dodson RJ, Daugherty SC, Madupu R, Angiuoli SV, Durkin AS, Haft DH, Vamathevan J, Khouri H, Utterback T, Lee C, Dimitrov G, Jiang L, Qin H, Weidman J, Tran K, Kang K, Hance IR, Nelson KE, Fraser CM (2005) J Bacteriol 187:2426
Vuong C, Kocianova S, Voyich JM, Yao Y, Fischer ER, DeLeo FR, Otto M (2004) J Biol Chem 279:54881
Cerca N, Jefferson KK, Maira-Litran T, Pier DB, Kelly-Quintos C, Goldmann DA, Azeredo J, Pier GB (2007) Infect Immun 75:3406
Dobinsky S, Kiel K, Rohde H, Bartscht K, Knobloch JKM, Horstkotte MA, Mack D (2003) J Bacteriol 185:2879
Gening ML, Tsvetkov YE, Pier GB, Nifantiev NE (2007) Carbohydr Res 342:567
Forman S, Bobrov AG, Kirillina O, Craig SK, Abney J, Fetherston JD, Perry RD (2006) Microbiology 152:3399
van den Berg B, Black PN, Clemons WM Jr, Rapoport TA (2004) Science 304:1506
Bobrov AG, Kirillina O, Perry RD (2007) Adv Exp Med Biol 603:201
Perry RD, Bobrov AG, Kirillina O, Jones HA, Pedersen L, Abney J, Fetherston JD (2004) J Bacteriol 186:1638
Christensen GD, Baldassarri L, Simpson WA (1994) Colonization of medical devices by coagulase-negative staphylococci. In: Bisno AL, Waldvogel FA (eds) Infections associated with indwelling medical devices. American Society of Microbiology, Washington DC, p 45chap 3,
Rupp ME, Ulphani JS, Fey PD, Mack D (1999) Infect Immun 67:2656
Rupp ME, Fey PD (2001) Methods Enzymol 336:206
Rupp ME, Ulphani JS, Fey PD, Bartscht K, Mack D (1999) Infect Immun 67:2627
Li H, Xu L, Wang J, Wen Y, Vuong C, Otto M, Gao Q (2005) Infect Immun 73:3188
Begun J, Gaiani JM, Rohde H, Mack D, Calderwood SB, Ausubel FM, Sifri CD (2007) PLoS Pathog 3:526
Vuong C, Voyich JM, Fischer ER, Braughton KR, Whitney AR, DeLeo FR, Otto M (2004) Cell Microbiol 6:269
Kristian SA, Birkenstock TA, Sauder U, Mack D, Gotz F, Landmann R (2008) J Infect Dis 197:1028
Cerca N, Jefferson KK, Oliveira R, Pier GB, Azeredo J (2006) Infect Immun 74:4849
Jäger S, Mack D, Rohde H, Horstkotte MA, Knobloch JKM (2005) Appl Environ Microbiol 71:5577
Zimmerli W, Waldvogel FA, Vaudaux P, Nydegger UE (1982) J Infect Dis 146:487
Francois P, Tu Quoc PH, Bisognano C, Kelley WL, Lew DP, Schrenzel J, Cramton SE, Götz F, Vaudaux P (2003) FEMS Immunol Med Microbiol 35:135
Chokr A, Leterme D, Watier D, Jabbouri S (2007) Microb Pathog 42:94
Fluckiger U, Ulrich M, Steinhuber A, Doring G, Mack D, Landmann R, Goerke C, Wolz C (2005) Infect Immun 73:1811
Zimmerli W, Lew PD, Waldvogel FA (1984) J Clin Invest 73:1191
Vandecasteele SJ, Peetermans WE, Merckx R, Van Eldere J (2003) J Infect Dis 188:730
Kristian SA, Golda T, Ferracin F, Cramton SE, Neumeister B, Peschel A, Götz F, Landmann R (2004) Microb Pathog 36:237
Kropec A, Maira-Litran T, Jefferson KK, Grout M, Cramton SE, Gotz F, Goldmann DA, Pier GB (2005) Infect Immun 73:6868
Darby C (2008) Trends Microbiol 16:158
Rohde H, Knobloch JKM, Horstkotte MA, Mack D (2001) Med Microbiol Immunol (Berl) 190:105
Kogan G, Sadovskaya I, Chaignon P, Chokr A, Jabbouri S (2006) FEMS Microbiol Lett 255:11
Frank KL, Hanssen AD, Patel R (2004) J Clin Microbiol 42:4846
Bateman A, Holden MT, Yeats C (2005) Bioinformatics 21:1301
Vandecasteele SJ, Peetermans WE, Merckx R, Rijnders BJ, Eldere J (2003) Clin Microbiol Infect 9:114
Roche FM, Meehan M, Foster TJ (2003) Microbiology 149:2759
Roche FM, Massey R, Peacock SJ, Day NP, Visai L, Speziale P, Lam A, Pallen M, Foster TJ (2003) Microbiology 149:643
Cucarella C, Solano C, Valle J, Amorena B, Lasa I, Penades JR (2001) J Bacteriol 183:2888
Tormo MA, Knecht E, Götz F, Lasa I, Penades JR (2005) Microbiology 151:2465
Kojima Y, Tojo M, Goldmann DA, Tosteson TD, Pier GB (1990) J Infect Dis 162:435
Kelly-Quintos C, Kropec A, Briggs S, Ordonez CL, Goldmann DA, Pier GB (2005) J Infect Dis 192:2012
Kelly-Quintos C, Cavacini LA, Posner MR, Goldmann D, Pier GB (2006) Infect Immun 74:2742
Cerca N, Maira-Litran T, Jefferson KK, Grout M, Goldmann DA, Pier GB (2007) Proc Natl Acad Sci U S A 104:7528
Kristinsson KG, Hastings JG, Spencer RC (1988) J Med Microbiol 27:207
Ramasubbu N, Thomas LM, Ragunath C, Kaplan JB (2005) J Mol Biol 349:475
Lu TK, Collins JJ (2007) Proc Natl Acad Sci U S A 104:11197
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Mack, D., Davies, A.P., Harris, L.G., Knobloch, J.K.M., Rohde, H. (2008). Staphylococcus epidermidis Biofilms: Functional Molecules, Relation to Virulence, and Vaccine Potential. In: Lindhorst, T., Oscarson, S. (eds) Glycoscience and Microbial Adhesion. Topics in Current Chemistry, vol 288. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2008_19
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