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Calix[n]arenes as Protein Sensors

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Creative Chemical Sensor Systems

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 277))

Abstract

The use of calix[n]arene derivatives for the sensing of proteins is described. Initially the properties of the calix[n]arenes are described. In order to better understand how the calix[n]arenes may be used for protein sensors, a detailed survey of the interactions between the molecules and amino acids and peptide is presented. The known complexes between proteins and various calix[n]arene derivatives is described and the biological activity of the molecules summarised. The use of calix[n]arenes as protein sensors observed by Schrader using amphiphilic calix[n]arenes shows that these molecules may allow nanomolar sensing. The major section of the work deals with the development of a para-sulfonato-calix[n]arene-based system for the prion protein responsible for bovine spongiform encephalitis and variant-Creutzfeldt–Jacobs disease(v-CJD) in humans. Initially, the development of the test was based on a Western Blot detection, however, the need for large scale testing after the discovery that blood transfusion may lead to infection with v-CJD led to the transfer of the technology to an ELISA-based test.

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Authors and Affiliations

  1. Assemblages Moléculaire d'Intérêt Biologique, Université Lyon I, 7 passage du Vercors, IBCP CNRS UMR 5086, 69367, Lyon cedex 07, France

    Anthony W. Coleman & Florent Perret

  2. Agence Française de Sécurité Sanitaire des Aliments, Site de Lyon, 69364, Lyon, France

    Aly Moussa

  3. BioMérieux Advanced Technology Unit, R&D New Markers Discovery, Chemin de L'Orme, 69280, Marcy L'Etoile, France

    Maryline Dupin, Yuping Guo & Hervi Perron

Authors
  1. Anthony W. Coleman
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  2. Florent Perret
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  3. Aly Moussa
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  4. Maryline Dupin
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  5. Yuping Guo
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  6. Hervi Perron
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Corresponding author

Correspondence to Anthony W. Coleman .

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Thomas Schrader

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Coleman, A.W., Perret, F., Moussa, A., Dupin, M., Guo, Y., Perron, H. (2007). Calix[n]arenes as Protein Sensors. In: Schrader, T. (eds) Creative Chemical Sensor Systems. Topics in Current Chemistry, vol 277. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2007_115

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