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Mitotic Oscillators as MP Graphs

  • Giuditta Franco
  • Pietro Hiram Guzzi
  • Vincenzo Manca
  • Tommaso Mazza
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4361)

Abstract

This paper proposes a model in terms of metabolic P graphs of a few important processes occurring during the biological phase where the choice is made to begin again mitosis or to arrest it. The cellular processes during this phase turn out to be especially interesting in the case of DNA damage, which triggers a specific destruction of Cdc25A phosphatase. It has important implications to understand the role of cell cycle checkpoints and the mechanism(s) guiding the proliferation of UV-resistant tumored cells. The formalism of metabolic P graphs highlights the relevant information of the biological network dynamics, and the individuation of few parameters rules the basic mechanisms of Cdc25A degradation, involving a couple of important mitotic oscillators.

Keywords

Output Gate Membrane Computing Complex Reaction Network Biological Phase Stoichiometric Network Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Giuditta Franco
    • 1
  • Pietro Hiram Guzzi
    • 2
  • Vincenzo Manca
    • 1
  • Tommaso Mazza
    • 2
  1. 1.Department of Computer ScienceUniversity of VeronaItaly
  2. 2.Magna Græcia University of CatanzaroItaly

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