Insulin Sensitivity and Plasma Glucose Appearance Profile by Oral Minimal Model in Normotensive and Normoglycemic Humans
To evaluate the whole body insulin sensitivity, S IW , and the rate of appearance, R a (t), of ingested glucose into plasma, the oral minimal model of glucose kinetics (OMM) was applied to insulinemia and glycemia data from six volunteer, normotensive and normoglycemic subjects, who underwent a 300 min oral glucose tolerance test (OGTT). Results from a full 22-sampling schedule (OGTT300/22), were compared with two reduced schedules consisting of 12 samples (OGTT300/12) and 11 samples (OGTT300/11), respectively. The three protocols yielded virtually the same values of insulin sensitivity (denoted as S 22 IW , S 12 IW and S 11 IW , respectively) with intraclass correlation coefficients being not lower than 0.74. The R a (t) profiles reproduced by the OMM after application to the OGTT300/22 and the OGTT300/12 data were practically indistinguishable, whereas the profile obtained from the OGTT300/11 was characterized by a 33% overshoot at the 30th minute, followed by a 22% undershoot at the 60th minute. Our results suggest that the reduced OGTT300/12is suitable to facilitate the assessment of insulin sensitivity and plasma glucose appearance profile in pathophysiological studies by the OMM.
KeywordsGlucose kinetics insulin action metabolic syndrome OGTT
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- 4.Dalla Man, C., Campioni, M., Polonsky, K.S., Basu, R., Rizza, R.A., Toffolo, G., Cobelli, C.: Two-hour seven-sample oral glucose tolerance test and meal protocol: minimal model assessment of beta-cell responsivity and insulin sensitivity in nondiabetic individuals. Diabetes 54, 3265–3273 (2005)CrossRefGoogle Scholar
- 6.Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III): JAMA 285, 2486–2497 (2001)Google Scholar
- 7.SAAM Institute: SAAM II User Guide. Seattle, WA (1997)Google Scholar
- 9.Carson, E.R., Cobelli, C., Finkelstein, L.: The Mathematical Modeling of Metabolic and Endocrine Systems. Wiley, New York (1983)Google Scholar
- 10.Fleiss, J.L.: Statistical Methods for Rates and Proportion, pp. 212–236. Wiley, New York (1980)Google Scholar
- 15.Wachters-Hagedoorn, R.E., Priebe, M.G., Heimweg, J.A., Heiner, A.M., Englyst, K.N., Holst, J.J., Stellaard, F., Vonk, R.J.: The rate of intestinal glucose absorption is correlated with plasma glucose-dependent insulinotropic polypeptide concentrations in healthy men. J. Nutr. 136, 1511–1516 (2006)Google Scholar