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Insulin Sensitivity and Plasma Glucose Appearance Profile by Oral Minimal Model in Normotensive and Normoglycemic Humans

  • Roberto Burattini
  • Fabrizio Casagrande
  • Francesco Di Nardo
  • Massimo Boemi
  • Pierpaolo Morosini
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4345)

Abstract

To evaluate the whole body insulin sensitivity, S IW , and the rate of appearance, R a (t), of ingested glucose into plasma, the oral minimal model of glucose kinetics (OMM) was applied to insulinemia and glycemia data from six volunteer, normotensive and normoglycemic subjects, who underwent a 300 min oral glucose tolerance test (OGTT). Results from a full 22-sampling schedule (OGTT300/22), were compared with two reduced schedules consisting of 12 samples (OGTT300/12) and 11 samples (OGTT300/11), respectively. The three protocols yielded virtually the same values of insulin sensitivity (denoted as S 22 IW , S 12 IW and S 11 IW , respectively) with intraclass correlation coefficients being not lower than 0.74. The R a (t) profiles reproduced by the OMM after application to the OGTT300/22 and the OGTT300/12 data were practically indistinguishable, whereas the profile obtained from the OGTT300/11 was characterized by a 33% overshoot at the 30th minute, followed by a 22% undershoot at the 60th minute. Our results suggest that the reduced OGTT300/12is suitable to facilitate the assessment of insulin sensitivity and plasma glucose appearance profile in pathophysiological studies by the OMM.

Keywords

Glucose kinetics insulin action metabolic syndrome OGTT 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Roberto Burattini
    • 1
  • Fabrizio Casagrande
    • 1
  • Francesco Di Nardo
    • 1
  • Massimo Boemi
    • 2
  • Pierpaolo Morosini
    • 3
  1. 1.Department of Electromagnetics and BioengineeringPolytechnic University of MarcheAnconaItaly
  2. 2.Metabolic Disease and Diabetes Unit, Italian National Institute of Research and Care on Aging (INRCA-IRCCS)AnconaItaly
  3. 3.Unit of Internal Medicine, “C. G. Mazzoni” General HospitalAscoli PicenoItaly

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