Tolerance Dependent on Timing/Amount of Antigen-Dose in an Asymmetric Idiotypic Network

  • Kouji Harada
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4252)


Physiological experiments demonstrate establishment of immunological tolerance is controlled by dose-timing and dose-amount of an antigen. My previous study reproduced the tolerance dependent on dose-timing of an antigen in a two Bcell clones network model with an “asymmetric” Bcell-Bcell interaction. This study first clarifies its mechanism using a dynamical system technique:nullcline analysis. Next, this study proposes a three Bcell clones network model with the same style of Bcell-Bcell interaction, and shows the model simulation can reproduce the tolerance dependent on dose-amount of an antigen: high and low zone tolerance. The success of this reproduction is worthy of attention. Because theoretical studies based on the traditional “symmetric” immune network modeling scheme have not been able to reproduce it well. This study would teach us the renewed recognition of “asymmetric” immune network modeling scheme.


Primary Immune Response Zone Tolerance Bcell Population Dose Amount Secondary Immune Response 


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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Kouji Harada
    • 1
  1. 1.Tokuyama College of TechnologyYamaguchiJapan

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