On the Society of Genome: Social Affiliation Network Analysis of Microarray Data

  • Jung Hun Ohn
  • Jihoon Kim
  • Ju Han Kim
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4223)


To investigate the structure of the genomic interaction network built from yeast gene-expression compendium dataset of hundreds of systematic perturbations, social affiliation network analysis methodologies were applied through quantifying various density, closeness and centrality measures and exploring core-periphery structures. Genes affected by a larger number of perturbations were found to be involved in responses to various environmental challenges. Deletion of essential genes was suggested to cause larger number of genes to be significantly up or down regulated. We explored the network structure made up of several sub-networks using core-periphery models to find ancient pathways. Glycolysis and TCA cycle have relatively core positions in the energy-related processes of yeast.


Social Network Analysis Betweenness Centrality Centralization Index Molecular Phenotype Yeast Gene Expression 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Jung Hun Ohn
    • 1
  • Jihoon Kim
    • 1
  • Ju Han Kim
    • 1
    • 2
  1. 1.Seoul National University Biomedical Informatics (SNUBI) 
  2. 2.Human Genome Research InstituteSeoul National University College of MedicineSeoulKorea

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