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Tumor Therapeutic Response and Vessel Tortuosity: Preliminary Report in Metastatic Breast Cancer

  • Elizabeth Bullitt
  • Nancy U. Lin
  • Matthew G. Ewend
  • Donglin Zeng
  • Eric P. Winer
  • Lisa A. Carey
  • J. Keith Smith
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4191)

Abstract

No current non-invasive method is capable of assessing the efficacy of brain tumor therapy early during treatment. We outline an approach that evaluates tumor activity via statistical analysis of vessel shape using vessels segmented from MRA. This report is the first to describe the changes in vessel shape that occur during treatment of metastatic brain tumors as assessed by sequential MRA. In this preliminary study of 16 patients undergoing treatment for metastatic breast cancer we conclude that vessel shape may predict tumor response several months in advance of traditional methods.

Keywords

Metastatic Brain Tumor Choroid Plexus Carcinoma Vessel Analysis Carcinomatous Meningitis Vessel Tortuosity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Elizabeth Bullitt
    • 1
  • Nancy U. Lin
    • 2
  • Matthew G. Ewend
    • 1
  • Donglin Zeng
    • 1
  • Eric P. Winer
    • 2
  • Lisa A. Carey
    • 1
  • J. Keith Smith
    • 1
  1. 1.CASILab, CB # 7062University of North CarolinaChapel HillUSA
  2. 2.Dana-Farber/Harvard Cancer CenterBostonUSA

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