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A New CAD System for the Evaluation of Kidney Diseases Using DCE-MRI

  • Ayman El-Baz
  • Rachid Fahmi
  • Seniha Yuksel
  • Aly A. Farag
  • William Miller
  • Mohamed A. El-Ghar
  • Tarek Eldiasty
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4191)

Abstract

Acute rejection is the most common reason of graft failure after kidney transplantation, and early detection is crucial to survive the transplanted kidney function. In this paper, we introduce a new approach for the automatic classification of normal and acute rejection transplants from Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI). The proposed algorithm consists of three main steps; the first step isolates the kidney from the surrounding anatomical structures by evolving a deformable model based on two density functions; the first function describes the distribution of the gray level inside and outside the kidney region and the second function describes the prior shape of the kidney. In the second step, a new nonrigid registration approach is employed to account for the motion of the kidney due to patient breathing. To validate our registration approach, we use a simulation of deformations based on biomechanical modelling of the kidney tissue using the finite element method (F.E.M.). Finally, the perfusion curves that show the transportation of the contrast agent into the tissue are obtained from the cortex and used in the classification of normal and acute rejection transplants. Applications of the proposed approach yield promising results that would, in the near future, replace the use of current technologies such as nuclear imaging and ultrasonography, which are not specific enough to determine the type of kidney dysfunction.

Keywords

Acute Rejection Deformable Model Dynamic Contrast Enhance Magnetic Resonance Image Prior Shape Registration Approach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Ayman El-Baz
    • 1
  • Rachid Fahmi
    • 1
  • Seniha Yuksel
    • 1
  • Aly A. Farag
    • 1
  • William Miller
    • 1
  • Mohamed A. El-Ghar
    • 2
  • Tarek Eldiasty
    • 2
  1. 1.Computer Vision and Image Processing LaboratoryUniversity of LouisvilleLouisville
  2. 2.Urology and Nephrology DepartmentUniversity of MansouraMansouraEgypt

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