Ultrasound Monitoring of Tissue Ablation Via Deformation Model and Shape Priors

  • Emad Boctor
  • Michelle deOliveira
  • Michael Choti
  • Roger Ghanem
  • Russell Taylor
  • Gregory Hager
  • Gabor Fichtinger
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4191)


A rapid approach to monitor ablative therapy through optimizing shape and elasticity parameters is introduced. Our motivating clinical application is targeting and intraoperative monitoring of hepatic tumor thermal ablation, but the method translates to the generic problem of encapsulated stiff masses (solid organs, tumors, ablated lesions, etc.) in ultrasound imaging. The approach involves the integration of the following components: a biomechanical computational model of the tissue, a correlation approach to estimate/track tissue deformation, and an optimization method to solve the inverse problem and recover the shape parameters in the volume of interest. Successful conver-gence and reliability studies were conducted on simulated data. Then ex-vivo studies were performed on 18 ex-vivo bovine liver samples previously ablated under ultrasound monitoring in controlled laboratory environment. While B-mode ultrasound does not clearly identify the development of necrotic lesions, the proposed technique can potentially segment the ablation zone. The same framework can also yield both partial and full elasticity reconstruction.


Ablation Zone Tissue Deformation Strain Image Ablate Lesion Displacement Estimation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Emad Boctor
    • 1
  • Michelle deOliveira
    • 2
  • Michael Choti
    • 2
  • Roger Ghanem
    • 3
  • Russell Taylor
    • 1
  • Gregory Hager
    • 1
  • Gabor Fichtinger
    • 1
  1. 1.Engineering Research CenterJohns Hopkins UniversityBaltimoreUSA
  2. 2.Department of SurgeryJohns Hopkins HospitalBaltimoreUSA
  3. 3.Department of Aerospace and Mechanical Eng.Univ. of Southern CaliforniaUSA

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