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Hippocampus-Specific fMRI Group Activation Analysis with Continuous M-Reps

  • Paul A. Yushkevich
  • John A. Detre
  • Kathy Z. Tang
  • Angela Hoang
  • Dawn Mechanic-Hamilton
  • María A. Fernández-Seara
  • Marc Korczykowski
  • Hui Zhang
  • James C. Gee
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4191)

Abstract

A new approach to group activation analysis in fMRI studies that test hypotheses focused on specific brain structures is presented and used to analyze hippocampal activation in a visual scene encoding study. The approach leverages the cm-rep method [10] to normalize hippocampal anatomy and project intra-subject hippocampal activation maps into a common reference space, eliminating normalization errors inherent in whole-brain approaches and guaranteeing that peaks detected in the random effects activation map are indeed associated with the hippocampus. When applied to real fMRI data, the method detects more significant hippocampal activation than the established whole-brain method.

Keywords

Statistical Parametric Mapping Hemodynamic Response Function Hippocampal Activation Anatomical Label Episodic Memory Encode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Ashburner, J., Friston, K.: Nonlinear spatial normalization using basis functions. Human Brain Mapping 7(4), 254–266 (1999)CrossRefGoogle Scholar
  2. 2.
    Evans, A., Collins, D., Mills, S., Brown, E., Kelly, R., Peters, T.: 3d statistical neuroanatomical models from 305 mri volumes. In: IEEE Nuclear Science Symposium and Medical Imaging Conference, pp. 1813–1817 (1993)Google Scholar
  3. 3.
    Fischl, B., Sereno, M.I., Dale, A.M.: Cortical surface-based analysis II: inflation, flattening, and a surface-based coordinate system. NeuroImage 9(2), 195–207 (1999)CrossRefGoogle Scholar
  4. 4.
    Frackowiak, R., Friston, K., Frith, C., Dolan, R., Mazziotta, J. (eds.): Human brain function. Academic Press, USA (1997)Google Scholar
  5. 5.
    Haller, J., Banerjee, A., Christensen, G., Gado, M., Joshi, S., Miller, M., Sheline, Y., Vannier, M., Csernansky, J.: Three-dimensional hippocampal MR morphometry by high-dimensional transformation of a neuroanatomic atlas. Radiology 202, 504–510 (1997)Google Scholar
  6. 6.
    Holmes, A., Friston, K.: Generalisability, random effects and population inference. NeuroImage 7, 754 (1998)Google Scholar
  7. 7.
    Pizer, S.M., Fletcher, P.T., Joshi, S., Thall, A., Chen, J.Z., Fridman, Y., Fritsch, D.S., Gash, A.G., Glotzer, J.M., Jiroutek, M.R., Lu, C., Muller, K.E., Tracton, G., Yushkevich, P., Chaney, E.L.: Deformable m-reps for 3D medical image segmentation. International Journal of Computer Vision 55(2), 85–106 (2003)CrossRefGoogle Scholar
  8. 8.
    Tosun, D., Prince, J.L.: Cortical surface alignment using geometry driven multispectral optical flow. In: International Conference on Information Processing in Medical Imaging, pp. 480–492 (2005)Google Scholar
  9. 9.
    Yushkevich, P., Zhang, H., Gee, J.: Parametric medial shape representation in 3-D via the Poisson partial differential equation with non-linear boundary conditions. In: Christensen, G., Sonka, M. (eds.) Information Processing in Medical Imaging, pp. 162–173 (2005)Google Scholar
  10. 10.
    Yushkevich, P.A., Zhang, H., Gee, J.C.: Statistical modeling of shape and appearance using the continuous medial representation. In: Duncan, J.S., Gerig, G. (eds.) MICCAI 2005. LNCS, vol. 3750, pp. 725–732. Springer, Heidelberg (2005)CrossRefGoogle Scholar
  11. 11.
    Zeineh, M.M., Engel, S.A., Thompson, P.M., Bookheimer, S.Y.: Dynamics of the hippocampus during encoding and retrieval of face-name pairs. Science 299(5606), 577–580 (2003)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Paul A. Yushkevich
    • 1
  • John A. Detre
    • 2
  • Kathy Z. Tang
    • 2
  • Angela Hoang
    • 2
  • Dawn Mechanic-Hamilton
    • 2
  • María A. Fernández-Seara
    • 2
  • Marc Korczykowski
    • 2
  • Hui Zhang
    • 1
  • James C. Gee
    • 1
  1. 1.Penn Image Computing and Science LaboratoryUniversity of Pennsylvania 
  2. 2.Center for Functional NeuroimagingUniversity of Pennsylvania 

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