Analysis of Skeletal Microstructure with Clinical Multislice CT

  • Joel Petersson
  • Torkel Brismar
  • Örjan Smedby
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4191)


In view of the great effects of osteoporosis on public health, it would be of great value to be able to measure the three-dimensional structure of trabecular bone in vivo as a means to diagnose and quantify the disease. The aim of this work was to implement a method for quantitative characterisation of trabecular bone structure using clinical CT.

Several previously described parameters have been calculated from volumes acquired with a 64-slice clinical scanner. Using automated region growing, distance transforms and three-dimensional thinning, measures describing the number, thickness and spacing of bone trabeculae was obtained. Fifteen bone biopsies were analysed. The results were evaluated using micro-CT as reference.

For most parameters studied, the absolute values did not agree well with the reference method, but several parameters were closely correlated with the reference method. The shortcomings appear to be due to the low resolution and high noise level. However, the high correlation found between clinical CT and micro-CT measurements suggest that it might be possible to monitor changes in the trabecular structure in vivo.


Trabecular Bone Bone Biopsy Trabecular Structure Trabecular Bone Structure Pattern Recognition Letter 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Joel Petersson
    • 1
    • 2
  • Torkel Brismar
    • 3
  • Örjan Smedby
    • 1
    • 2
    • 4
  1. 1.Center for Medical Image Science and Visualization (CMIV)Linköping UniversitySweden
  2. 2.Department of Science and Technology (ITN)Linköping UniversitySweden
  3. 3.Department of RadiologyKarolinska University Hospital HuddingeSweden
  4. 4.Department of Medicine and Care (IMV)Linköping UniversitySweden

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