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A Novel MRI Texture Analysis of Demyelination and Inflammation in Relapsing-Remitting Experimental Allergic Encephalomyelitis

  • Yunyan Zhang
  • Jennifer Wells
  • Richard Buist
  • James Peeling
  • V. Wee Yong
  • J. Ross Mitchell
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4190)

Abstract

We have developed a novel multiscale localized image texture analysis technique, based upon the polar Stockwell Transform (PST). In this paper we characterized image texture in vivo using the PST in histologically verified lesion areas in T2-weighted MRI of an animal model of multiple sclerosis. Both high and low frequency signals, representing inflammation and demyelination, were significantly increased in pathological regions compared to normal control tissue. This suggests that this new local spatial-frequency measure of image texture may provide a sensitive and precise indication of disease activity.

Keywords

Multiple Sclerosis Prussian Blue Image Texture Multiple Sclerosis Lesion Normal Appear White Matter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Yunyan Zhang
    • 1
    • 2
  • Jennifer Wells
    • 2
  • Richard Buist
    • 3
  • James Peeling
    • 3
  • V. Wee Yong
    • 2
  • J. Ross Mitchell
    • 1
    • 2
  1. 1.Department of RadiologyUniversity of CalgaryCalgary, Alberta
  2. 2.Department of Clinical NeurosciencesUniversity of CalgaryCalgary, AB
  3. 3.Department of RadiologyUniversity of ManitobaWinnipeg, MB

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