Linear-Time Haplotype Inference on Pedigrees Without Recombinations

  • M. Y. Chan
  • Wun-Tat Chan
  • Francis Y. L. Chin
  • Stanley P. Y. Fung
  • Ming-Yang Kao
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4175)


In this paper, a linear-time algorithm, which is optimal, is presented to solve the haplotype inference problem for pedigree data when there are no recombinations and the pedigree has no mating loops. The approach is based on the use of graphs to capture SNP, Mendelian and parity constraints of the given pedigree.


Family Problem Pedigree Data Heterozygous Locus Haplotype Inference Haplotype Pair 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • M. Y. Chan
    • 1
  • Wun-Tat Chan
    • 1
  • Francis Y. L. Chin
    • 1
  • Stanley P. Y. Fung
    • 2
  • Ming-Yang Kao
    • 3
  1. 1.Department of Computer ScienceUniversity of Hong KongHong Kong
  2. 2.Department of Computer ScienceUniversity of LeicesterLeicesterUK
  3. 3.Department of Electrical Engineering and Computer ScienceNorthwestern UniversityUSA

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