Neural Model of Dopaminergic Control of Arm Movements in Parkinson’s Disease Bradykinesia

  • Vassilis Cutsuridis
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4131)


Patients suffering from Parkinson’s disease display a number of symptoms such a resting tremor, bradykinesia, etc. Bradykinesia is the hallmark and most disabling symptom of Parkinson’s disease1 (PD). Herein, a basal ganglia-cortico-spinal circuit for the control of voluntary arm movements in PD bradykinesia is extended by incorporating DAergic innervation of cells in the cortical and spinal components of the circuit. The resultant model simulates successfully several of the main reported effects of DA depletion on neuronal, electromyographic and movement parameters of PD bradykinesia.


Neural Model Globus Pallidus Internal Dopamine Depletion Large Amplitude Movement Dopaminergic Control 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Vassilis Cutsuridis
    • 1
  1. 1.Computational Intelligence Laboratory, Institute of Informatics and TelecommunicationsNational Center for Scientific Research “Demokritos”Athens

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