Advertisement

Did Germinal Centers Evolve Under Differential Effects of Diversity vs Affinity?

  • Jose Faro
  • Jaime Combadao
  • Isabel Gordo
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4163)

Abstract

The classical view on the process of mutation and affinity maturation that occurs in GCs assumes that their major role is to generate high affinity levels of serum Abs, as well as a dominant pool of high affinity memory B cells, through a very efficient selection process. Here we present a model that considers different types of structures where a mutation selection process occurs, with the aim at discussing the evolution of Germinal Center reactions. Based on the results of this model, we suggest that in addition to affinity maturation, the diversity generated during the GC reaction may have also been important in the evolution towards the presently observed highly organized structure of GC in higher vertebrates.

Keywords

Deleterious Mutation High Vertebrate Lower Vertebrate Primary Immune Response Germinal Center Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Janeway, C., Travers, P., Walport, M., Shlomchik, M.: Immunobiology: the immune system in health and disease, 6th edn. Garland Science, New York (2004)Google Scholar
  2. 2.
    Flajnik, M.F.: Comparative analyses of immunoglobulin genes: surprises and portents. Nat. Rev. Immunol. 2, 688–698 (2002)CrossRefGoogle Scholar
  3. 3.
    MacLennan, I.C.: Germinal centers. Annu. Rev. Immunol. 12, 117–139 (1994)CrossRefGoogle Scholar
  4. 4.
    Kelsoe, G.: In situ studies of the germinal center reaction. Adv. Immunol. 60, 267–288 (1995)CrossRefGoogle Scholar
  5. 5.
    Fagarasan, S., Muramatsu, M., Suzuki, K., Nagaoka, H., Hiai, H., Honjo, T.: Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298, 1424–1427 (2002)CrossRefGoogle Scholar
  6. 6.
    Gordo, I., Dionisio, F.: Nonequilibrium model for estimating parameters of deleterious mutations. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 71, 031907 (2005)CrossRefGoogle Scholar
  7. 7.
    Gordo, I., Charlesworth, B.: On the speed of Muller’s ratchet. Genetics 156, 2137–2140 (2000)Google Scholar
  8. 8.
    Bachtrog, D., Gordo, I.: Adaptive evolution of asexual populations under Muller’s ratchet. Evolution Int. J. Org. Evolution 58, 1403–1413 (2004)Google Scholar
  9. 9.
    Kimura, M.: The neutral theory of molecular evolution. Cambridge University Press, Cambridge (1983)CrossRefGoogle Scholar
  10. 10.
    Charlesworth, B., Morgan, M.T., Charlesworth, D.: The effect of deleterious mutations on neutral molecular variation. Genetics 134, 1289–1303 (1993)Google Scholar
  11. 11.
    Smith, J.M., Haigh, J.: The hitch-hiking effect of a favourable gene. Genet. Res. 23, 23–35 (1974)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Jose Faro
    • 1
    • 2
  • Jaime Combadao
    • 1
  • Isabel Gordo
    • 1
  1. 1.Instituto Gulbenkian de CiênciaEstudos Avançados de OeirasOeirasPortugal
  2. 2.Edificio de Ciencias ExperimentáisUniversidade de VigoVigoSpain

Personalised recommendations