Advertisement

Association Research on Potassium Channel Subtypes and Functional Sites

  • Peng Wu
  • Xia Li
  • Shaoqi Rao
  • Wei Jiang
  • Chuanxing Li
  • Jie Zhang
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4115)

Abstract

Potassium channels, a goup of membrane proteins and found in virtually all cells, are of crucial physiological importance for understanding cell biology and channelopathy. Studying the association of channel subtypes with their functional sites, and mining the functional sites mostly relevant to channel subtypes, can not only enhance molecular classification of potassium channels but only provide some clues for the functional targets. Here, we proposed to use functional sites profiles as features, where the functional sites are often used to characterize ion channels in biomedical research domains. We employed a novel integrated decision method to recognize the functional sites subset that is mostly relevant to the differentiation of potassium channel subtypes.

Keywords

Potassium Channel Functional Site Channel Subtype Copper Iron Ensemble Vote 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Chou, K.C.: Analytical Biochemistry  233, 1–14 (1996)Google Scholar
  2. 2.
    Li, X., Rao, S., Wang, Y., Gong, B.: Gene Mining: A Novel and Powerful Ensemble Decision Approach to Hunting for Disease Genes Using Microarray Expression Profiling. Nucl. Acids Res. 32, 2685–2694 (2004)CrossRefGoogle Scholar
  3. 3.
    Berman, H.M., Stbrook, J., Feng, Z., Gilliland, G.N., Bhat, T., Weissig, H., Shindyalov, I.N., Bourne, P.E.: The Protein Data Bank Nucleic Acids Research 28, 235–242 (2000)Google Scholar
  4. 4.
    Morera, F.J., Wolff, D.: External Copper Inhibits the Activity of The Large-Conductance Calcium- and Voltage-sensitive Potassium Channel from Skeletal Muscle. Journal of Membrane Biology 192, 65–72 (2003)CrossRefGoogle Scholar
  5. 5.
    Ivanisenko, V.A., Pintus, S.S., Grigorovich, D.A., Kolchanov, N.A.: PDBSite: a database of the 3D structure of protein functional sites. Nucleic Acids Res. V33, D183–D187 (2005)Google Scholar
  6. 6.
    Ivanisenko, V.A., Pintus, S.S., Grigorovich, D.A., Kolchanov, N.: PDBSiteScan: a program for searching for active, binding and posttranslational modification sties in the 3D structrues of proteins. Nucleic Acids Res. 554, W549–W554 (2004)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Peng Wu
    • 1
  • Xia Li
    • 1
    • 2
  • Shaoqi Rao
    • 1
    • 3
  • Wei Jiang
    • 1
  • Chuanxing Li
    • 1
  • Jie Zhang
    • 1
  1. 1.Department of BioinformaticsHarbin Medical UniversityHarbinP.R. China
  2. 2.Department of Computer ScienceHarbin Institute of TechnologyHarbinChina
  3. 3.Departments of Cardiovascular Medicine and Molecular CardiologyThe Cleveland Clinic FoundationClevelandUSA

Personalised recommendations