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An Analysis of Gene Expression Relationships Between Periodically Expressed Genes in the Hela Cells

  • Yun Xiao
  • Xia Li
  • Shaoqi Rao
  • Juan Wang
  • Yun Zhang
  • Lei Du
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4115)

Abstract

The availability of increasingly accumulated time-series expression profiles has provided the data structures to study the temporal relationship between genes. The aims of the study were to explore the modes of relationship between the genes periodically expressed in human HeLa cell cycle, and to reversely engineer the dynamic networks of gene transcription. We also studied the phase-specific properties of the genetic relationships by decomposing the whole network into the sub-networks according to the cell cycling phases. The results demonstrated that the gene-gene relationships within a same phase or between different phases followed different modes.

Keywords

HeLa Cell Cell Cycling Cell Cycling Phase Gene Ramp Expression Relationship 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Yun Xiao
    • 1
  • Xia Li
    • 1
    • 2
  • Shaoqi Rao
    • 1
    • 3
  • Juan Wang
    • 1
  • Yun Zhang
    • 1
  • Lei Du
    • 1
  1. 1.Department of BioinformaticsHarbin Medical UniversityHarbinP.R. China
  2. 2.Biomedical Engineering InstituteCapital University of Medical SciencesBeijingP.R. China
  3. 3.Departments of Cardiovascular Medicine and Molecular CardiologyThe Cleveland Clinic FoundationClevelandUSA

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