Role of 3T High Field BOLD fMRI in Brain Cortical Mapping for Glioma Involving Eloquent Areas
The study included 26 patients with glioma involving motor cortical areas to assess the value of preoperative blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) in 3T high magnetic field for brain cortical mapping operation. With the guidance of preoperative mapping, all patients received microsurgery under awake anaesthesia to identify motor area by direct electrical stimulation. The tumor was resected at maximum with preservation of eloquent areas. Preoperative mapping was succeeded in twenty-three patients; Primary motor cortex, premoter area, supplementary motor area and cerebellar motor related area were localized. There was good correlation between preoperative fMRI and intraoperative cortical stimulation results. BOLD-fMRI in 3T high magnetic field could non-invasively localize the brain motor cortex and show its relationship to lesion before operation, which may help neurosurgeons to optimize the surgical planning, guide the intraoperative motor areas mapping and resect the tumor with brain eloquent areas preservation.
KeywordsBlood Oxygen Level Dependent Supplementary Motor Area Blood Oxygen Level Dependent Signal Central Sulcus Eloquent Area
Unable to display preview. Download preview PDF.
- 3.Brell, M., Conesa, G., Acebes, J.J.: Intraoperative cortical mapping in the surgical resection of low-grade gliomas located in eloquent areas. Neurocirugia (Astur) 14(6), 491–503 (2003)Google Scholar
- 4.Haberg, A., Kvistad, K.A., Unsgard, G., et al.: Preoperative blood oxygen level-dependent functional magnetic resonance imaging in patients with primary brain tumors: clinical application and outcome. Neurosurgery 54(4), 902–914 (2004) (discussion 914–915)Google Scholar
- 6.Gaillard, W.D., Hertz-Pannier, L., Mott, S.H., et al.: Functional anatomy of cognitive development: fMRI of verbal fluency in children and adults. Neurology 54(1), 180–185 (2000)Google Scholar
- 9.Holodny, A.I., Schulder, M., Liu, W.C., et al.: The effect of brain tumors on BOLD functional MR imaging activation in the adjacent motor cortex: implications for image-guided neurosurgery. AJNR Am. J. Neuroradiol. 21(8), 1415–1422 (2000)Google Scholar
- 10.Holodny, A.I., Schulder, M., Liu, W.C., et al.: Decreased BOLD functional MR activation of the motor and sensory cortices adjacent to a glioblastoma multiforme: implications for image-guided neurosurgery. AJNR Am. J. Neuroradiol. 20(4), 609–612 (1999)Google Scholar
- 11.Allison, J.D., Meador, K.J., Loring, D.W., et al.: Functional MRI cerebral activation and deactivation during finger movement. Neurology 54(1), 135–142 (2000)Google Scholar
- 14.Kober, H., Nimsky, C., Moller, M., et al.: Correlation of Sensorimotor Activation with Functional Magnetic Resonance Imaging and Magnetoencephalography in Presurgical Functional Imaging: A Spatial Analysis. NeuroImage (14), 1214–1228 (2001)Google Scholar
- 15.Jaaskelainen, J., Randell, T.: Awake craniotomy in glioma surgery. Acta Neurochir Suppl. 88, 31–35 (2003)Google Scholar