Multi-modal Image Registration Using Dirichlet-Encoded Prior Information

  • Lilla Zöllei
  • William Wells
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4057)


We present a new objective function for the registration of multi-modal medical images. Our novel similarity metric incorporates both knowledge about the current observations and information gained from previous registration results and combines the relative influence of these two types of information in a principled way. We show that in the absence of prior information, the method reduces approximately to the popular entropy minimization approach of registration and we provide a theoretical comparison of incorporating prior information in our and other currently existing methods. We also demonstrate experimental results on real images.


Mutual Information Kullback Leibler Dirichlet Distribution Correct Alignment Joint Entropy 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Lilla Zöllei
    • 1
  • William Wells
    • 1
  1. 1.MIT, CSAILCambridgeUSA

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