Correlating Cone-Beam CT and Large-Section Histology Image Sets: Initial Results Using a Surgical Lumpectomy Specimen
Radiographic signs indicating the presence of a malignancy are a result of the morphology and composition of the lesion. Assessment of the size, distribution, extent and location of disease are crucial in guiding patient management. Often mammographic estimates of size and extent are underestimated. Radiologic/pathologic correlation between features is often by indirect classification methods rather than a direct, whole-volume, one-to-one spatial correlation between radiologic and pathologic images. As an initial step toward understanding how tumour morphology and composition yields a mammographic sign, we have begun work on correlating whole-mount histology sections to cone-beam computed tomography (CBCT) images of the same specimen. Preliminary results for a lumpectomy sample containing a 3.5 cm invasive ductal carcinoma qualitatively show a remarkable correspondence between CBCT slices and histology sections. Ultimately, the 3D CBCT data could be used to predict mammographic features, which could then be correlated precisely to the anatomy of the tumour.
KeywordsHistology Section Fiducial Marker CBCT Image Fibroglandular Tissue Mammographic Feature
Unable to display preview. Download preview PDF.
- 1.Coombs, J.H., Hubbard, E., Hudson, K., Wunderlich, C., VanMeter, S., Bell, J.L., Gwin, J.L.: Ductal Carcinoma in Situ of the Breast: The correlation of pathologic and mammographic features with extent of disease. Am. Surg. 63, 1079–1083 (1997)Google Scholar
- 2.Rafferty, E.A., Kopans, D.B., Wu, T., Moore, R.H.: Tomosynthesis: A new tool for breast cancer detection. Breast Cancer Res Treat 94, S2 (2005)Google Scholar
- 5.Feder, J.M., de Paredes, E.S., Hogge, J.P., Wilken, J.J.: Unusual breast lesions – A radiologic-pathologic correlation. Radiographics 19, S11–S26 (1999)Google Scholar
- 7.Clarke, G., Eidt, S., Peressotti, C., Zubovits, J., Mawdsley, G., Morgan, T., Rico, D., Yaffe, M.: Development of Three-Dimensional Digital Breast Histopathology Imaging. In: IWDM 2004, pp. 484–489 (2005)Google Scholar