Abstract
A new problem in phylogenetic inference is presented, based on recent biological findings indicating a strong association between reversals (aka inversions) and repeats. These biological findings are formalized here in a new mathematical model, called repeat-annotated phylogenetic trees (RAPT). We show that, under RAPT, the evolutionary process — including both the tree-topology as well as internal node genome orders — is uniquely determined, a property that is of major significance both in theory and in practice. Furthermore, the repeats are employed to provide linear-time algorithms for reconstructing both the genomic orders and the phylogeny, which are NP-hard problems under the classical model of sorting by reversals (SBR).
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Swidan, F., Ziv-Ukelson, M., Pinter, R.Y. (2006). On the Repeat-Annotated Phylogenetic Tree Reconstruction Problem. In: Lewenstein, M., Valiente, G. (eds) Combinatorial Pattern Matching. CPM 2006. Lecture Notes in Computer Science, vol 4009. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11780441_14
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DOI: https://doi.org/10.1007/11780441_14
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