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SYMBIONIC: A European Initiative on the Systems Biology of the Neuronal Cell

  • Ivan Arisi
  • Paola Roncaglia
  • Vittorio Rosato
  • Antonino Cattaneo
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3939)

Abstract

To understand how genes, proteins and metabolites make up the whole organism, a systemic view is demanded, that is to conceive genes and proteins more as part of a network than as isolated entities. Molecular function becomes then a function of cellular context and not only an individual property. This change of attitude is accompanied by the recognition that bioinformatics plays an indispensable role in extracting information from the huge amounts of data stemming from recent “-omics” research. Such systemic view of cells demands the capacity to quantitatively predict, rather than simply qualitatively describe, cell behavior. In fact, in parallel with the data-driven research approach that focuses on speedy handling and analyzing of the currently available large-scale data, a new approach called “model-driven research” is gradually gaining power. Model-driven research aims at setting up a biological model by combining the knowledge of the system with related data and simulates the behavior of the system in order to understand its biological mechanisms.

Keywords

Neuronal Cell System Biology Systemic View European Initiative Special Purpose Hardware 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Ivan Arisi
    • 1
  • Paola Roncaglia
    • 2
  • Vittorio Rosato
    • 3
  • Antonino Cattaneo
    • 2
  1. 1.Lay Line Genomics S.p.A.RomaItaly
  2. 2.Scuola Internazionale Superiore di Studi AvanzatiTriesteItaly
  3. 3.Ente per le Nuove Tecnologie, l’Energia e l’AmbienteRomaItaly

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