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Interaction of Nanoparticles with Lipid Monolayers and Lung Surfactant Films

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Book cover Measuring Biological Impacts of Nanomaterials

Part of the book series: Bioanalytical Reviews ((BIOREV,volume 5))

Abstract

It has been shown that the interactions of nanoparticles with lipid and lipid–peptide monolayers mimicking the lung surfactant strongly depend on the physical properties of the nanoparticles, their size, and on the physical properties of the surface film. Hydrophobic nanoparticles have been found inserting into fluid phases of lipid monolayers. They have an adverse effect on the functional properties of the pulmonary surfactant, which strongly depends on the nanoparticle size. But how NPs disturb or inhibit this surfactant function still remains unclear. Experimental evidences gathered under physiologically relevant conditions or from in vivo studies are still lacking. The present review summarizes systematic investigations on simplified model systems of the lung surfactant using high-resolution bioanalytical techniques that have provided valuable hints and indications about the interactions of NPs with the surfactant layer at the molecular level. Further studies are needed in particular for a more detailed understanding of the mechanism by which NPs are capable of crossing the surfactant barrier even though they experience a very different and individual free energy barrier at the interface.

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Abbreviations

AFM:

Atomic force microscopy

BODIPY-PC:

2-(4, 4-difluoro-5-methyl-4-bora-3a, 4a-diaza-s-indacene-3-dodecanoyl)-1-hexadecanoyl-sn-glycero-3-phosphocholine

CL:

Cholesterol

CTAB:

Cetyltrimethylammonium bromide

DMAB:

Didodecyldimethylammonium bromide

DPPC:

Dipalmitoyl phosphatidylcholine

DPPE:

Dipalmitoyl phosphatidylethanolamine

DPPG:

Dipalmitoyl phosphatidylglycerols

DPPS:

Dipalmitoyl phosphatidyl serine

DTAB:

Dodecyltrimethylammonium bromide

EMM:

Endothelial model cell membranes

Hepes:

2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid

LC:

Liquid-condensed phase

LE:

Liquid-expanded phase

LS:

Lung surfactant

NPs:

Nanoparticles

PBS:

Phosphate-buffered saline

PI:

Phosphatidylinositol

POPG:

Palmitoyl oleoyl phosphatidylglycerol

PVA:

Polyvinyl alcohol

SM:

Sphingomyelin

SP-B:

Surfactant-specific protein B

SP-C:

Surfactant-specific protein C

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Authors and Affiliations

  1. Institute for Biochemistry, University of Münster, Wilhelm Klemm Str. 2, 48149, Münster, Germany

    Mridula Dwivedi, Amit Kumar Sachan & Hans-Joachim Galla

Authors
  1. Mridula Dwivedi
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  2. Amit Kumar Sachan
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  3. Hans-Joachim Galla
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Correspondence to Hans-Joachim Galla .

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Editors and Affiliations

  1. University of Regensburg, Regensburg, Germany

    Joachim Wegener

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Dwivedi, M., Sachan, A.K., Galla, HJ. (2014). Interaction of Nanoparticles with Lipid Monolayers and Lung Surfactant Films. In: Wegener, J. (eds) Measuring Biological Impacts of Nanomaterials. Bioanalytical Reviews, vol 5. Springer, Cham. https://doi.org/10.1007/11663_2014_9

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