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Multi-directional Width-Bounded Geometric Separator and Protein Folding

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Algorithms and Computation (ISAAC 2005)

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Abstract

We introduce the concept of multi-directional width-bounded geometric separator and get improved separator for the grid graph, which improves exact algorithm for the protein folding problem in the HP-model. For a grid graph G with n grid points P, there exists a separator A ⊆ P such that A has less than or equal to 1.02074\(\sqrt{n}\) points, and GA has two disconnected subgraphs with less than or equal to \({2 \over 3}n\) nodes on each of them. We also derive 0.7555\(\sqrt{n}\) lower bound for such a separator on grid graph. The previous upper bound record for the grid graph \(2 \over 3\)-separator is 1.129\(\sqrt{n}\) [6].

This research is supported by Louisiana Board of Regents fund under contract number LEQSF(2004-07)-RD-A-35.

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References

  1. Alon, N., Seymour, P., Thomas, R.: Planar Separator. SIAM J. Discr. Math. 7(2), 184–193 (1990)

    Article  MathSciNet  Google Scholar 

  2. Berger, B., Leighton, T.: Protein folding in the hydrophobic-hydrophilic (HP) model is NP-complete. Journal of Computational Biology 5, 27–40 (1998)

    Article  Google Scholar 

  3. Crescenzi, P., Goldman, D., Papadimitriou, C., Piccolboni, A., Yannakakis, M.: On the complexity of protein folding. Journal of computational biology 5, 423–465 (1998)

    Article  Google Scholar 

  4. Djidjev, H.N.: On the problem of partitioning planar graphs. SIAM Journal on Discrete Mathematics 3(2), 229–240 (1982)

    Article  MATH  MathSciNet  Google Scholar 

  5. Djidjev, H.N., Venkatesan, S.M.: Reduced constants for simple cycle graph separation. Acta informatica 34, 231–234 (1997)

    Article  MathSciNet  Google Scholar 

  6. Fu, B., Wang, W.: A \(2^{O(n^{1-1/d}\log n)}\)-time algorithm for d-dimensional protein folding in the HP-model. In: Díaz, J., Karhumäki, J., Lepistö, A., Sannella, D. (eds.) ICALP 2004. LNCS, vol. 3142, pp. 630–644. Springer, Heidelberg (2004)

    Chapter  Google Scholar 

  7. Fu, B.: Theory and application of width bounded geometric separator, Electronic Colloquium on Computational Complexity, TR05-13 (2005)

    Google Scholar 

  8. Gazit, H.: An improved algorithm for separating a planar graph, manuscript, USC (1986)

    Google Scholar 

  9. Lau, K.F., Dill, K.A.: A lattice statistical mechanics model of the conformational and sequence spaces of proteins. Macromolecules 22, 3986–3997 (1989)

    Article  Google Scholar 

  10. Lau, K.F., Dill, K.A.: Theory for protein mutability and biogenesis. Proc. Natl. Acad. Sci. 87, 638–642 (1990)

    Article  Google Scholar 

  11. Lipton, R.J., Tarjan, R.: A separator theorem for planar graph. SIAM J. Appl. Math. 36, 177–189 (1979)

    Article  MATH  MathSciNet  Google Scholar 

  12. Miller, G.L., Teng, S.-H., Thurston, W.P., Vavasis, S.A.: Separators for sphere-packings and nearest neighbor graphs. J. ACM 44(1), 1–29 (1997)

    Article  MATH  MathSciNet  Google Scholar 

  13. Smith, W.D., Wormald, N.C.: Application of geometric separator theorems. In: Smith, W.D., Wormald, N.C. (eds.) FOCS 1998, pp. 232–243 (1998)

    Google Scholar 

  14. Spielman, D.A., Teng, S.H.: Disk packings and planar separators. In: 12th Annual ACM Symposium on Computational Geometry, pp. 349–358 (1996)

    Google Scholar 

  15. Pach, J., Agarwal, P.K.: Combinatorial Geometry. Wiley-Interscience Publication, Hoboken (1995)

    MATH  Google Scholar 

  16. Weinstock, R.: Calculus of variations. McGraw-Hill, New York (1952)

    MATH  Google Scholar 

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Fu, B., Oprisan, S.A., Xu, L. (2005). Multi-directional Width-Bounded Geometric Separator and Protein Folding. In: Deng, X., Du, DZ. (eds) Algorithms and Computation. ISAAC 2005. Lecture Notes in Computer Science, vol 3827. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11602613_99

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  • DOI: https://doi.org/10.1007/11602613_99

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30935-2

  • Online ISBN: 978-3-540-32426-3

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