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Multidisciplinary Investigation into Adult Stem Cell Behavior

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Transactions on Computational Systems Biology III

Part of the book series: Lecture Notes in Computer Science ((TCSB,volume 3737))

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We are part of a multi-disciplinary team investigating new understandings of stem cell behaviour, and specifically looking novel ideas about how adult stem cells behave and organise themselves in the human body. We have used different methods and mechanisms for investigating and interpreting these new ideas from medical science. These have included mathematical modelling, simulation and visualisation as well as a series of art pieces that have resulted from looking at the overall nature of our combined multi-disciplinary attempt to investigate new theories of biological organisation. In this paper we look at several issues relating to our project. First, we provide reasons for why formal models and simulations are needed to explore this growing area of research. Is there an argument to suggest that we need simulations as a way in to understanding various properties of stem cells that are observed in wet lab experiments? Next, an introduction on current theoretical models of stem cells is presented along with an outline of some of the problems and limitations of these approaches. We then provide an overview of our agent-based model of stem cells, and discuss strategies for implementing this model as a simulation and its subsequent visualisation. Then we discuss the role of the artist (the second author) in developing our model and simulation and the influence of the artwork/exhibition on the other members in our team. Our premise is that artists can conceptualise scientific theories without the standard discipline-specific constraints, and thereby potentially influence the development of scientific theories, their mathematical formulation; and their associated aesthetics. Finally, we argue that for the field of bioinformatics to move forward in a holistic and cohesive manner more multi-disciplinary efforts such as ours would be of significant benefit to this research area [20]. This paper might be viewed as an advert for the benefits of multi-disciplinary teams in understanding new experimental data in medicine and biology.

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  1. Agur, Z., Daniel, Y., Ginosar, Y.: The universal properties of stem cells as pinpointed by a simple discrete model. Mathematical Biology 44, 79–86 (2002)

    Article  MATH  MathSciNet  Google Scholar 

  2. Cariani, P.: Emergence and artificial life. In: Langton, C., Taylor, C., Farmer, J., Rasmussen, S. (eds.) Artificial Life II, pp. 775–797 (1991)

    Google Scholar 

  3. d’Inverno, M., Kinny, D., Luck, M.: Interaction protocols in Agentis. In: ICMAS 1998 Proceedings of the Third International Conference on Multi-Agent Systems, pp. 112–119. IEEE Computer Society, Los Alamitos (1998)

    Chapter  Google Scholar 

  4. d’Inverno, M., Luck, M.: Understanding Agent Systems, 2nd edn. Springer, Heidelberg (2004)

    MATH  Google Scholar 

  5. d’Inverno, M., Theise, N.D., Prophet, J.: Mathematical modelling of stem cells: a complexity primer for the stem cell biologist. In: Potten, C., Watson, J., Clarke, R., Renehan, A. (eds.) Tissue Stem Cells: Biology and Applications, Marcel Dekker (2005) (to appear)

    Google Scholar 

  6. Eastwood, M., Mudera, V., McGrouther, D., Brown, R.: Effect of mechanical loading on fibroblast populated collagen lattices: Morphological changes. Cell Motil Cytoskel 40(1), 13–21 (1998)

    Article  Google Scholar 

  7. Fishwick, P., Diehl, S., Prophet, J., Lwgren, J.: Perspectives on aesthetic computing. Leonardo: The Journal of the International Society for The Arts, Sciences and Technology (in Press)

    Google Scholar 

  8. Gonzalez, P., et al.: Cellulat: an agent-based intracellular signalling model. BioSystems, 171–185 (2003)

    Google Scholar 

  9. Hilgevoord, J., Uffink, J.: The uncertainty principle. In: Zalta, E.N. (ed.) The Stanford Encyclopedia of Philosophy (Winter 2001)

    Google Scholar 

  10. Kirkland, M.: A phase space model of hemopoiesis and the concept of stem cell renewal. Exp Hematol 32, 511–519 (2004)

    Article  Google Scholar 

  11. Knoepsel, K.: Information visualization. In: Approaching Cyberculture: Humanists as Actors in the Development of Technology conference, Blekinge Institute of Technology and Georgia Institute of Technology, Karlskrona, Sweden (2003)

    Google Scholar 

  12. Kosuth, J.: Art After Philosophy and After: Collected Writings 1966-1990. In: Gabriele, G. (ed.). MIT Press, Cambridge (1991)

    Google Scholar 

  13. Krause, D.S., Theise, N.D., Collector, M.I., Henegariu, O., Hwang, S., Gardner, R., Neutzel, S., Sharkis, S.J.: Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 369–377 (2001)

    Article  Google Scholar 

  14. Lewitt, S.: Paragraphs on Conceptual Art. Artforum, Summer Issue (1967)

    Google Scholar 

  15. Loeffler, M., Roeder, I.: Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models – a conceptual approach. Cells Tissues Organs 171, 8–26 (2002)

    Article  Google Scholar 

  16. Luck, M., d’Inverno, M.: A conceptual framework for agent definition and development. The Computer Journal 44(1), 1–20 (2001)

    Article  MATH  Google Scholar 

  17. Luck, M., Ashri, R., d’Inverno, M.: Agent-Based Software Development. Artech House (2004)

    Google Scholar 

  18. Novak, M.: Alienspace (2004),

  19. Prophet, J.: Sublime ecologies and artistic endeavours: artificial life, interactivity and the internet. Leonardo: The Journal of the International Society for the Arts, Sciences & Technology 29(5) (1996)

    Google Scholar 

  20. Prophet, J., d’Inverno, M.: Transdisciplinary research in cell. In: Fishwick, P. (ed.) Aesthetic Computing. MIT Press, Cambridge (2004) (to appear)

    Google Scholar 

  21. Prophet, J., Ride, P.: Wonderful: Visions of the near future book. In: Fusco, M. (ed.) Active Daydreaming: the nature of collaboration. BKD Special Projects, pp. 66–71 (2001)

    Google Scholar 

  22. Prophet, J.: Staining space image 1 (2004), ,

  23. Prophet, J.: Staining space image 2 (2004),

  24. Prophet, J.: Staining space image 3 (2004),

  25. Prophet, J.: Staining space image 4. html (2004),

  26. Roeder, I.: Dynamical modelling of hematopoietic stem cell organisation. Ph.D. Dissertation Leipzig University (2003)

    Google Scholar 

  27. Roeder, I., Loeffler, M.: A novel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity. Exerimental Hematology 30, 853–861 (2002)

    Article  Google Scholar 

  28. Spivey, J.M.: The Z Notation: A Reference Manual. Prentice-Hall, Englewood Cliffs (1992)

    Google Scholar 

  29. Theise, N.D.: New principles of cell plasticity. C R Biologies 325, 1039–1043 (2003)

    Article  Google Scholar 

  30. Theise, N.D., d’Inverno, M.: Understanding cell lineages as complex adaptive systems. Blood, Cells, Molecules and Diseases 32, 17–20 (2003)

    Article  Google Scholar 

  31. Theise, N.D., Krause, D.S.: Toward a new paradigm of cell plasticity. Leukemia 16, 542–548 (2002)

    Article  Google Scholar 

  32. Viswanathan, S., Zandstra, P.: Toward predictive models of stem cell fate. Cryotechnology Review 41(2), 1–31 (2004)

    Google Scholar 

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d’Inverno, M., Prophet, J. (2005). Multidisciplinary Investigation into Adult Stem Cell Behavior. In: Priami, C., Merelli, E., Gonzalez, P., Omicini, A. (eds) Transactions on Computational Systems Biology III. Lecture Notes in Computer Science(), vol 3737. Springer, Berlin, Heidelberg.

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  • Print ISBN: 978-3-540-30883-6

  • Online ISBN: 978-3-540-31446-2

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