Abstract
The Chagas disease or Tripanosomiasis Americana affects between 16 and 18 million people in endemic areas. This disease affects the beating rate of infected patients’ cardiomyocytes. At the Molecular Biology of Chagas Disease Laboratory in Argentina the effect of isolated patient’s serum antibodies is studied over rat cardiomyocyte cultures. In this work an image processing application to measure the beating rate of this culture over video sequences is presented. This work is organized as follows. Firstly, a preliminary analysis of the problem is introduced, isolating the main characteristics of the problem. Secondly, a Monte Carlo experiment is designed and used to evaluate the robustness and validity of the algorithm. Finally, an algorithm of order O(T(N log N + N)) for tracking cardiomyocyte membranes is presented, where T is the number of frames and N is the maximum area of the membrane. Its performance is compared against the standard beating rate measure method.
Keywords
- Video Sequence
- Initial Curve
- Monte Carlo Experiment
- Image Processing Application
- Beating Rate
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
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© 2005 Springer-Verlag Berlin Heidelberg
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Wassermann, D., Mejail, M. (2005). Development and Validation of an Algorithm for Cardiomyocyte Beating Frequency Determination. In: Sanfeliu, A., Cortés, M.L. (eds) Progress in Pattern Recognition, Image Analysis and Applications. CIARP 2005. Lecture Notes in Computer Science, vol 3773. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11578079_44
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DOI: https://doi.org/10.1007/11578079_44
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-29850-2
Online ISBN: 978-3-540-32242-9
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