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A Bioinformatic Approach to Epigenetic Susceptibility in Non-disjunctional Diseases

  • Ismael Ejarque
  • Guillermo López-Campos
  • Michel Herranz
  • Francisco-Javier Vicente
  • Fernando Martín-Sánchez
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3745)

Abstract

The aim of this work is to present a fully “in silico” approach for the identification of genes that might be involved in the susceptibility for non disjunction diseases and their regulation by methylation processes. We have carried out a strategy based on the use of online available bioinformatics databases and programs for the retrieval and identification of interesting genes. As result we have obtained 29 putative susceptibility genes regulated by methylation processes. We were neither on the need of developing new software nor carry out clinical laboratory experiments for the identification of these genes. We consider that this “in silico” methodology is robust enough to provide candidate genes that must be checked “in vivo” due to the clinical relevance of non disjunction diseases with the aim of providing new tools and criteria for their diagnostics.

Keywords

Gene Ontology Bioinformatic Approach Transcription Starting Point Database Issue Folate Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Ismael Ejarque
    • 1
    • 2
  • Guillermo López-Campos
    • 2
  • Michel Herranz
    • 3
  • Francisco-Javier Vicente
    • 2
  • Fernando Martín-Sánchez
    • 2
  1. 1.Ambulatorio di Genetica MedicaOspedale GallieraGenovaItaly
  2. 2.Medical Bioinformatics DepartmentInstitute of Health Carlos IIIMajadahonda. MadridSpain
  3. 3.Cancer Epigenetics Laboratory, Molecular Pathology ProgramSpanish National Cancer CentreMadridSpain

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