Intravascular Ultrasound-Based Imaging of Vasa Vasorum for the Detection of Vulnerable Atherosclerotic Plaque

  • Sean M. O’Malley
  • Manolis Vavuranakis
  • Morteza Naghavi
  • Ioannis A. Kakadiaris
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3749)


Vulnerable plaques are dangerous atherosclerotic lesions that bear a high risk of complications that can lead to heart attacks and strokes. These plaques are known to be chronically inflamed. The vasa vasorum (VV) are microvessels that nourish vessel walls. Proliferation of VV is part of the “response to injury” phenomenon in the process of plaque formation. Recent evidence has shown strong correlations between neovessel formation and macrophage infiltration in atherosclerotic plaque, suggesting VV density as a surrogate marker of plaque inflammation and vulnerability. We have developed a novel method for imaging and analyzing the density and perfusion of VV in human coronary atherosclerotic plaques using intravascular ultrasound (IVUS). Images are taken during the injection of a microbubble contrast agent and the spatiotemporal changes of the IVUS signal are monitored using enhancement-detection techniques. We present analyses of in vivo human coronary cases that, for the first time, demonstrate the feasibility of IVUS imaging of VV.


Atherosclerotic Plaque Intravascular Ultrasound Vulnerable Plaque Ultrasound Contrast Agent Cardiac Phase 
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  1. 1.
    Naghavi, M., Libby, P., Falk, E., Casscells, S., Litovsky, S.: et al. From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: Parts I-II. Circulation 108, 1664–1672/1772–1778 (2003)Google Scholar
  2. 2.
    Kolodgie, F., Gold, H., Burke, A., Fowler, D., et al.: Intraplaque hemorrhage and progression of coronary atheroma. New England J. of Med. 349, 2316–2325 (2003)CrossRefGoogle Scholar
  3. 3.
    Hayden, M., Tyagi, S.: Vasa vasorum in plaque angiogenesis, metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: a malignant transformation. Cardiovasc Diabetol. 3 (2004)Google Scholar
  4. 4.
    Tearney, G., Yabushita, H., Houser, S., Aretz, H., Jang, I.K., et al.: Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography. Circulation 107, 113–119 (2003)CrossRefGoogle Scholar
  5. 5.
    Khan, T., Soller, B., Naghavi, M., Casscells, W.: Tissue pH determination for the detection of metabolically active, inflamed vulnerable plaques using near-infrared spectroscopy: An in-vitro feasibility study. Cardiology 103, 10–16 (2005)CrossRefGoogle Scholar
  6. 6.
    Go, V., Bhatt, M., Hendel, R.: The diagnostic and prognostic value of ECG-gated SPECT myocardial perfusion imaging. J. Nucl. Med. 45, 912–921 (2004)Google Scholar
  7. 7.
    Winter, P., Morawski, A., Caruthers, S., Fuhrhop, R., Zhang, H., et al.: Molecular imaging of angiogenesis in early-stage atherosclerosis with α v β 3-integrin-targeted nanoparticles. Circulation 108, 2270–2274 (2003)CrossRefGoogle Scholar
  8. 8.
    Olszewski, M., Wahle, A., Vigmostad, S., Sonka, M.: Multidimensional segmentation of coronary intravascular ultrasound images using knowledge-based methods. In: Proc. SPIE Medical Imaging, vol. 5747, pp. 496–504 (2005)Google Scholar
  9. 9.
    Gossl, M., Rosol, M., Malyar, N., Fitzpatrick, L., Beighley, P., Zamir, M., Ritman, E.: Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries. Anat. Rec. 272A, 526–537 (2003)CrossRefGoogle Scholar
  10. 10.
    Zhu, H., Oakeson, K., Friedman, M.: Retrieval of cardiac phase from IVUS sequences. Proc. SPIE Medical Imaging 5035, 135–146 (2003)Google Scholar
  11. 11.
    Bruzzone, L., Prieto, D.: Automatic analysis of the difference image for unsupervised change detection. IEEE Trans Geo Remote Sensing 38, 1171–1182 (2000)CrossRefGoogle Scholar
  12. 12.
    Carlier, S., Kakadiaris, I.A., Dib, N., Vavuranakis, M., Stefanadis, C., O’Malley, S.M., et al.: Vasa vasorum imaging: A new window to the clinical detection of vulnerable atherosclerotic plaques. Curr. Athero. Rep. 7, 164–169 (2005)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Sean M. O’Malley
    • 1
  • Manolis Vavuranakis
    • 2
  • Morteza Naghavi
    • 3
  • Ioannis A. Kakadiaris
    • 1
  1. 1.Visual Computing Lab, Dept. of Computer ScienceUniv. of Houston 
  2. 2.Dept. of CardiologyUniv. of Athens 
  3. 3.Association for Eradication of Heart Attack 

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