Dynamic Modeling, Prediction and Analysis of Cytotoxicity on Microelectronic Sensors

  • Biao Huang
  • James Z. Xing
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3614)


This paper is concerned with dynamic modeling, prediction and analysis of cell cytotoxicity. A real-time cell electronic sensing (RT-CES) system has been used for label-free, dynamic measurements of cell responses to toxicant. Cells were grown onto the surfaces of the microelectronic sensors. Changes in cell number expressed as cell index (CI) have been recorded on-line as time series. The CI data are used for dynamic modeling in this paper. The developed models are verified using data that do not participate in the modeling. Optimal multi-step ahead predictions are calculated and compared with the actual CI. A new framework for dynamic cytotoxicity system analysis is established. Through the analysis of the system impulse response, we have observed that there are considerably similarities between the impulse response curves and the raw dynamic data, but there are also some striking differences between the two, particularly in terms of the initial and final cell killing effects. It is shown that dynamic modeling has great potential in modeling cell dynamics in the presence of toxicant and predicting the response of the cells.


Impulse Response Model Predictive Control Cell Index Mercury Toxicant Time Series Gene Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bar-Joseph, Z.: Analyzing time series gene expression data. Bioinformatics 20(16), 2493–2503 (2004)CrossRefGoogle Scholar
  2. 2.
    Huang, B., Malhotra, A., Tamayo, E.C.: Model predictive control relevant identification and validation. Chemical Engineering Sciences 58, 2389–2401 (2003)CrossRefGoogle Scholar
  3. 3.
    Ljung, L.: System Identification, 2nd edn. Prentice-Hall, Englewood Cliffs (1999)Google Scholar
  4. 4.
    Seborg, D.E., Edgar, T.F., Mellichamp, D.A.: Process Dynamics and Control. John Wiley & Sons, Chichester (1989)Google Scholar
  5. 5.
    Soderstrom, T., Stoica, P.: System Identification. Prentice Hall International, UK (1989)Google Scholar
  6. 6.
    Xing, J.Z., Zhu, L., Jackson, J.A., Gabos, S., Sun, X.J., Wang, X., Xu, X.: Dynamic monitoring of cytotoxicity on microelectronic sensors. Chem. Res. Toxicol. 18, 154–161 (2005)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Biao Huang
    • 1
  • James Z. Xing
    • 2
  1. 1.Department of Chemical and Materials EngineeringUniversity of AlbertaEdmontonCanada
  2. 2.Department of Laboratory Medicine and PathologyUniversity of AlbertaEdmontonCanada

Personalised recommendations