Methods for Identifying and Tracking Phase Singularities in Computational Models of Re-entrant Fibrillation
The dangerous cardiac arrhythmias of tachycardia and fibrillation are most often sustained by re-entry. Re-entrant waves rotate around a phase singularity, and the identification and tracking of phase singularities allows the complex activity observed in both experimental and computational models of fibrillation to be quantified. In this paper we present preliminary results that compare two methods for identifying phase singularities in a computational model of fibrillation in 2 spatial dimensions. We find that number of phase singularities detected using each method depends on choosing appropriate parameters for each algorithm, but that if an appropriate choice is made there is little difference between the two methods.
KeywordsVentricular Fibrillation Topological Charge Spiral Wave Membrane Voltage Phase Singularity
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- 3.Rogers, J.M., Huang, J., Smith, W.M., Ideker, R.E.: Incidence, evolution, and spatial distribution of functional reentry during ventricular fibrillation in pigs. Circulation Research 84, 945–954 (1999)Google Scholar
- 4.Xie, F., Qu, Z.L., Yang, J., Baher, A., Weiss, J.N., Garfinkel, A.: A simulation study of the effects of cardiac anatomy in ventricular fibrillation. Journal of Clinical Investigation 113, 686–693 (2004)Google Scholar
- 5.Chen, P.S., Wu, T.J., Ting, C.T., Karagueuzian, H.S., Garfinkel, A., Lin, S.F., Weiss, J.N.: A tale of two fibrillations. Circulation 108, 2298–2203 (2003)Google Scholar
- 6.Zaitsev, A.V., Berenfeld, O., Mironov, S.F., Jalife, J., Pertsov, A.M.: Distribution of excitation frequencies on the epicardial and endocardial surfaces of fibrillating ventricular wall of the sheep heart. Circulation Research 86, 408–417 (2000)Google Scholar