Reentry Anchoring at a Pair of Pulmonary Vein Ostia
Recent findings in a sheep model of atrial fibrillation support the hypothesis that an organized micro-reentry could be the maintaining mechanism of the arrhythmia (mother wavelet). According to these studies we constructed a two dimensional computer model of tissue in the region around a pair of pulmonary vein ostia and investigated anchoring of a reentry wave at these ostia. We used the Luo Rudy phase I ionic current model to describe membrane kinetics and generated two different stages of electrical remodelling of the cells by varying the slow inward calcium current. Our attempt to initiate a stable reentry failed for cells with higher action potential duration and higher rate adaption. By simulating a higher stadium of electrical remodelling we finally were successful, and we were able to produce a periodic reentry. This led us to the conclusion that a low rate adaption (high electrical remodelling) facilitates organized activity in the atria.
KeywordsPulmonary Vein Action Potential Duration Functional Block Rate Adaption Electrical Remodelling
Unable to display preview. Download preview PDF.
- 4.Mandapati, R., Skanes, A., Chen, J., Berenfeld, O., Jalife, J.: Stable microreentrant sources as a mechansism of atrial fibrillation in the isolated sheep heart. Circulation 101, 194–199 (2000)Google Scholar
- 6.Pappone, C., Rosiano, S., Oreto, G., Tocchi, M., Gugliotta, F., Vicedomini, G., Salvati, A., Dicandia, C., Mazzone, P., Santinelli, V., Gulletta, S., Chierchia, S.: Circumferential radiofrequency ablation of pulmonary vein ostia: A new anatomic approach for curing atrial fibrillation. Circulation 102, 2619–2628 (2000)Google Scholar
- 7.Luo, C., Rudy, Y.: A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circ. Res. 68, 1501–1526 (1991)Google Scholar
- 8.Ten Tusscher, K., Panfilov, A.: Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model. Am. J. Physiol. Heart Circ. Physiol. 284, H542–H548 (2002)Google Scholar
- 10.Ramirez, R.J., Nattel, S., Courtemanche, M.: Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling. Am. J. Physiol. Heart Circ. Physiol. 279, H1767–H1785 (2000)Google Scholar
- 12.Harrild, D.M., Henriquez, C.S.: A Computer Model of Normal Conduction in the Human Atria. Circ. Res. 87, e25–e36 (2000)Google Scholar
- 13.Winfree, A.T.: Rotors, fibrilation and dimensionality. In: Panfilov, A.V., Holden, A.V. (eds.) Computational Biology of the Heart, pp. 101–135. John Wiley & Sons, Chichester (1997)Google Scholar