Reentry Anchoring at a Pair of Pulmonary Vein Ostia

  • L. Wieser
  • G. Fischer
  • F. Hintringer
  • S. Y. Ho
  • B. Tilg
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3504)


Recent findings in a sheep model of atrial fibrillation support the hypothesis that an organized micro-reentry could be the maintaining mechanism of the arrhythmia (mother wavelet). According to these studies we constructed a two dimensional computer model of tissue in the region around a pair of pulmonary vein ostia and investigated anchoring of a reentry wave at these ostia. We used the Luo Rudy phase I ionic current model to describe membrane kinetics and generated two different stages of electrical remodelling of the cells by varying the slow inward calcium current. Our attempt to initiate a stable reentry failed for cells with higher action potential duration and higher rate adaption. By simulating a higher stadium of electrical remodelling we finally were successful, and we were able to produce a periodic reentry. This led us to the conclusion that a low rate adaption (high electrical remodelling) facilitates organized activity in the atria.


Pulmonary Vein Action Potential Duration Functional Block Rate Adaption Electrical Remodelling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • L. Wieser
    • 1
  • G. Fischer
    • 1
  • F. Hintringer
    • 2
  • S. Y. Ho
    • 3
  • B. Tilg
    • 1
  1. 1.Institute for Biomedical Signal Processing and ImagingUniversity for Health Sciences, Medical Informatics and Technology (UMIT)Hall in TirolAustria
  2. 2.Department for CardiologyUniversity Hospital InnsbruckInnsbruckAustria
  3. 3.Imperial College and Royal Brompton & Harefield HospitalsNational Heart & Lung InstituteLondonUK

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