Mining Candidate Viruses as Potential Bio-terrorism Weapons from Biomedical Literature
In this paper we present a semantic-based data mining approach to identify candidate viruses as potential bio-terrorism weapons from biomedical literature. We first identify all the possible properties of viruses as search key words based on Geissler’s 13 criteria; the identified properties are then defined using MeSH terms. Then, we assign each property an importance weight based on domain experts’ judgment. After generating all the possible valid combinations of the properties, we search the biomedical literature, retrieving all the relevant documents. Next our method extracts virus names from the downloaded documents for each search keyword and identifies the novel connection of the virus according to these 4 properties. If a virus is found in the different document sets obtained by several search keywords, the virus should be considered as suspicious and treated as candidate viruses for bio-terrorism. Our findings are intended as a guide to the virus literature to support further studies that might then lead to appropriate defense and public health measures.
KeywordsWest Nile Virus Search Keyword Hepatitis Delta Virus Rift Valley Fever Rift Valley Fever Virus
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- 1.The Association of State and Territorial Health Officials (ASTHO). Public Health Prepar-edness: A Progress Report – First Six Months (ATAIP Indicators Project) (2003)Google Scholar
- 2.Büchen-Osmond, C.: Taxonomy and Classification of Viruses. In: Manual of Clinical Microbiology, 8th edn., vol. 2, pp. 1217–1226. ASM Press, Washington (2003)Google Scholar
- 3.Diaz, R., et al.: National Advisory Committee on Children and Terrorism – Report to the Secretary of DHHS (2003)Google Scholar
- 5.Frist, B.: When Every Moment Counts – What You Need to Know About Bio-terrorism from the Senate’s Only Doctor. Rowman and Littlefield (2002)Google Scholar
- 6.Geissler, E. (ed.): Biological and toxin weapons today. SIPRI, Oxford (1986)Google Scholar
- 8.Gursky, E.A.: Drafted to Fight Terror. U.S. Public Health on the Front Lines of Biological Defense, ANSER (2004)Google Scholar
- 9.Lane, S.P., Beugelsdijk, T., Patel, C.K.: FirePower in the Lab – Automation in the Fight Against Infectious Diseases and Bioterrorism. John Henry Press, DC (1999)Google Scholar
- 11.Swanson, D.: Fish-oil, Raynaud’s Syndrome, and undiscovered public knowledge. Perspectives in Biology and Medicine 30(1), 7–18 (1986)Google Scholar
- 13.Web site updated regularly by the Agency for Health Care Research and Quality, US DHHS on bioterrorism and emerging infectious disease agents accessible at: http://www.bioterrorism.uab.edu/EIPBA/vhf/summary.html