Abstract
Intracellular calcium (Ca2+) concentration plays an important regulatory role in a number of cellular processes. Cellular influx of Ca2+ activates intracellular signaling pathways that in turn regulate gene expression. Studies have identified over 300 genes and 30 transcription factors which are regulated by intracellular Ca2+ [1,2]. Fluctuation of intracellular Ca2+ levels is also known to regulate intracellular metabolism by activation of mitochondrial matrix dehydrogenases. The subsequent effects on the tri-carboxylic acid cycle increase the supply of reducing equivalents (NADH, FADH2), stimulating increased flux of electrons through the respiratory chain [3]. Most importantly, Ca2+ is a key signaling molecule in excitation-contraction (EC) coupling, the process by which electrical activation of the cell is coupled to mechanical contraction and force generation.
Keywords
- Ventricular Myocytes
- Action Potential Duration
- Ryanodine Receptor
- Dependent Inactivation
- Action Potential Prolongation
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 2005 Springer-Verlag Berlin/Heidelberg
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Winslow, R., Hinch, R., Greenstein, J. (2005). Mechanisms and Models of Cardiac Excitation-Contraction Coupling. In: Sneyd, J. (eds) Tutorials in Mathematical Biosciences II. Lecture Notes in Mathematics, vol 1867. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11406501_4
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DOI: https://doi.org/10.1007/11406501_4
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-25439-3
Online ISBN: 978-3-540-31438-7
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