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Mechanisms and Models of Cardiac Excitation-Contraction Coupling

Part of the Lecture Notes in Mathematics book series (LNMBIOS,volume 1867)

Abstract

Intracellular calcium (Ca2+) concentration plays an important regulatory role in a number of cellular processes. Cellular influx of Ca2+ activates intracellular signaling pathways that in turn regulate gene expression. Studies have identified over 300 genes and 30 transcription factors which are regulated by intracellular Ca2+ [1,2]. Fluctuation of intracellular Ca2+ levels is also known to regulate intracellular metabolism by activation of mitochondrial matrix dehydrogenases. The subsequent effects on the tri-carboxylic acid cycle increase the supply of reducing equivalents (NADH, FADH2), stimulating increased flux of electrons through the respiratory chain [3]. Most importantly, Ca2+ is a key signaling molecule in excitation-contraction (EC) coupling, the process by which electrical activation of the cell is coupled to mechanical contraction and force generation.

Keywords

  • Ventricular Myocytes
  • Action Potential Duration
  • Ryanodine Receptor
  • Dependent Inactivation
  • Action Potential Prolongation

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 2005 Springer-Verlag Berlin/Heidelberg

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Winslow, R., Hinch, R., Greenstein, J. (2005). Mechanisms and Models of Cardiac Excitation-Contraction Coupling. In: Sneyd, J. (eds) Tutorials in Mathematical Biosciences II. Lecture Notes in Mathematics, vol 1867. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11406501_4

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