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Modeling IP3-Dependent Calcium Dynamics in Non-Excitable Cells

  • J. Sneyd
Chapter
Part of the Lecture Notes in Mathematics book series (LNM, volume 1867)

Abstract

Calcium is critically important for a vast array of cellular functions, as discussed in detail in Chap. 1. There are a number of Ca2+ control mechanisms operating on different levels, all designed to ensure that Ca2+ is present in sufficient quantity to perform its necessary functions, but not in too great a quantity in the wrong places. Prolonged high concentrations of Ca2+ are toxic. For instance, it is known that cellular Ca2+ overload can trigger apoptotic cell death, a process in which the cell kills itself. Indeed, control of Ca2+ homeostasis is so crucial that even just disruptions in the normal Ca2+ fluxes can lead to initiation of active cell death. There are many reviews of Ca2+ physiology in the literature: in 2003 an entire issue of Nature Reviews was devoted to the subject and contains reviews of Ca2+ homeostasis (Berridge et al., 2003), extracellular Ca2+ sensing (Hofer and Brown, 2003), Ca2+ signaling during embryogenesis (Webb and Miller, 2003), the Ca2+-apoptosis link (Orrenius et al., 2003), and the regulation of cardiac contractility by Ca2+ (MacLennan and Kranias, 2003). Other useful reviews are Berridge, (1997) and Carafoli (2002).

Keywords

Hopf Bifurcation Xenopus Oocyte Homoclinic Orbit Spiral Wave Calcium Wave 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin/Heidelberg 2005

Authors and Affiliations

  • J. Sneyd
    • 1
  1. 1.University of AucklandNew Zealand

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