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Role of ASIC1a in Normal and Pathological Synaptic Plasticity

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Reviews of Physiology, Biochemistry and Pharmacology

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 177))

Abstract

Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are broadly distributed in the mammalian nervous system where they play important roles in a variety of physiological processes, including neurotransmission and memory-related behaviors. In the last few years, we and others have investigated the role of ASIC1a in different forms of synaptic plasticity especially in the CA1 area of the hippocampus. This review summarizes the latest research linking ASIC1a to synaptic function either in physiological or pathological conditions. A better understanding of how these channels are regulated in brain circuitries relevant to synaptic plasticity and memory may offer novel targets for pharmacological intervention in neuropsychiatric and neurological disorders.

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Abbreviations

AD:

Alzheimer’s disease

ASICs:

Acid-sensing ion channels

CNS:

Central nervous system

EAE:

Experimental autoimmune encephalomyelitis

EPSCs:

Excitatory post-synaptic currents

LTD:

Long-term depression

LTP:

Long-term potentiation

MS:

Multiple sclerosis

NAc:

Nucleus accumbens

NMDA:

N-methyl-D-aspartate

PcTx1:

Psalmotoxin-1

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Contributions

DM conceived the idea and prepared the manuscript, RN prepared the manuscript and reviewed the drafts. All authors contributed to the writing and final approval of the manuscript.

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Laboratory of Pharmacology of Synaptic Plasticity, EBRI Rita Levi-Montalcini Foundation, Rome, Italy

    Dalila Mango & Robert Nisticò

  2. School of Pharmacy, University of Rome Tor Vergata, Rome, Italy

    Robert Nisticò

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  1. Dalila Mango
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  2. Robert Nisticò
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  1. Department of Biology, University of Copenhagen, Copenhagen, Denmark

    Stine Helene Falsig Pedersen

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Mango, D., Nisticò, R. (2020). Role of ASIC1a in Normal and Pathological Synaptic Plasticity. In: Pedersen, S.H.F. (eds) Reviews of Physiology, Biochemistry and Pharmacology . Reviews of Physiology, Biochemistry and Pharmacology, vol 177. Springer, Cham. https://doi.org/10.1007/112_2020_45

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