Ezrin Orchestrates Signal Transduction in Airway Cells

  • Lei-Miao Yin
  • Ting-Ting Duan
  • Luis UlloaEmail author
  • Yong-Qing YangEmail author
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 174)


Ezrin is a critical structural protein that organizes receptor complexes and orchestrates their signal transduction. In this study, we review the ezrin-meditated regulation of critical receptor complexes, including the epidermal growth factor receptor (EGFR), CD44, vascular cell adhesion molecule (VCAM), and the deleted in colorectal cancer (DCC) receptor. We also analyze the ezrin-meditated regulation of critical pathways associated with asthma, such as the RhoA, Rho-associated protein kinase (ROCK), and protein kinase A (cAMP/PKA) pathways. Mounting evidence suggests that ezrin plays a role in controlling airway cell function and potentially contributes to respiratory diseases. Ezrin can participate in asthma pathogenesis by affecting bronchial epithelium repair, T lymphocyte regulation, and the contraction of the airway smooth muscle cells. These studies provide new insights for the design of novel therapeutic strategies for asthma treatment.


Actin-binding proteins Airway cells Asthma Ezrin 



This work was supported by the National Natural Science Foundation of China (Nos. 81473760, 81574058); the Shanghai Talent Development Fund (No. 201610); the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (JZ2016010).


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© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Laboratory of Molecular Biology, Shanghai Research Institute of Acupuncture and Meridian, Yue Yang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina
  2. 2.Department of Surgery, Center of Immunology and Inflammation, Rutgers-New Jersey Medical SchoolRutgers UniversityNewarkUSA

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