TRPs in the Brain

  • Rudi Vennekens
  • Aurelie Menigoz
  • Bernd Nilius
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 163)


The Transient receptor potential (TRP) family of cation channels is a large protein family, which is mainly structurally uniform. Proteins consist typically of six transmembrane domains and mostly four subunits are necessary to form a functional channel. Apart from this, TRP channels display a wide variety of activation mechanisms (ligand binding, G-protein coupled receptor dependent, physical stimuli such as temperature, pressure, etc.) and ion selectivity profiles (from highly Ca2+ selective to non-selective for cations). They have been described now in almost every tissue of the body, including peripheral and central neurons. Especially in the sensory nervous system the role of several TRP channels is already described on a detailed level. This review summarizes data that is currently available on their role in the central nervous system. TRP channels are involved in neurogenesis and brain development, synaptic transmission and they play a key role in the development of several neurological diseases.


Obsessive Compulsive Disorder Neurite Outgrowth Growth Cone Transient Receptor Potential Transient Receptor Potential Channel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors are supported by the FWO Vlaanderen and the Bijzonder Onderzoeksfonds of the KU Leuven. We would like to thank all members of the Laboratory of Ion Channel Research, KU Leuven, for stimulating discussions.


  1. Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, Ueyama T, Matsuda T, Seki T, Sakai N, Saito N (2008) Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis. J Biol Chem 283:19854–19863PubMedCrossRefGoogle Scholar
  2. Aguiar DC, Terzian AL, Guimaraes FS, Moreira FA (2009) Anxiolytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats. Psychopharmacology 205:217–225PubMedCrossRefGoogle Scholar
  3. Aita VM, Liu J, Knowles JA, Terwilliger JD, Baltazar R, Grunn A, Loth JE, Kanyas K, Lerer B, Endicott J, Wang Z, Penchaszadeh G, Gilliam TC, Baron M (1999) A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus. Am J Hum Genet 64:210–217PubMedCrossRefGoogle Scholar
  4. Amaral MD, Pozzo-Miller L (2007a) BDNF induces calcium elevations associated with IBDNF, a non-selective cationic current mediated by TRPC channels. J Neurophysiol 98:2476–2482PubMedCrossRefGoogle Scholar
  5. Amaral MD, Pozzo-Miller L (2007b) TRPC3 channels are necessary for brain-derived neurotrophic factor to activate a nonselective cationic current and to induce dendritic spine formation. J Neurosci 27:5179–5189PubMedCrossRefGoogle Scholar
  6. Amaral MD, Chapleau CA, Pozzo-Miller L (2007) Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: potential implications for Rett syndrome. Pharmacol Ther 113:394–409PubMedCrossRefGoogle Scholar
  7. Bai JZ, Lipski J (2010) Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. Neurotoxicology 31:204–214PubMedCrossRefGoogle Scholar
  8. Bargal R, Avidan N, Ben-Asher E, Olender Z, Zeigler M, Frumkin A, Raas-Rothschild A, Glusman G, Lancet D, Bach G (2000) Identification of the gene causing mucolipidosis type IV. Nat Genet 26:118–123PubMedCrossRefGoogle Scholar
  9. Bargal R, Avidan N, Olender T, Ben Asher E, Zeigler M, Raas-Rothschild A, Frumkin A, Ben-Yoseph O, Friedlender Y, Lancet D, Bach G (2001) Mucolipidosis type IV: novel MCOLN1 mutations in Jewish and non-Jewish patients and the frequency of the disease in the Ashkenazi Jewish population. Hum Mutat 17:397–402PubMedCrossRefGoogle Scholar
  10. Bassi MT, Manzoni M, Monti E, Pizzo MT, Ballabio A, Borsani G (2000) Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV. Am J Hum Genet 67:1110–1120PubMedGoogle Scholar
  11. Becker EBE, Oliver PL, Glitsch MD, Banks GT, Achillic F, Hardy A, Noland PM, Fisher EMC, Davies KE (2009) A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. Proc Natl Acad Sci (USA) 106:6706–6711CrossRefGoogle Scholar
  12. Becker EB, Fogel BL, Rajakulendran S, Dulneva A, Hanna MG, Perlman SL, Geschwind DH, Davies KE (2011) Candidate screening of the TRPC3 gene in cerebellar ataxia. Cerebellum 10:296–299PubMedCrossRefGoogle Scholar
  13. Beis D, Schwarting RK, Dietrich A (2011) Evidence for a supportive role of classical transient receptor potential 6 (TRPC6) in the exploration behavior of mice. Physiol Behav 102:245–250PubMedCrossRefGoogle Scholar
  14. Belrose JC, Xie YF, Gierszewski LJ, Macdonald JF, Jackson MF (2012) Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons. Mol Brain 5:11PubMedCrossRefGoogle Scholar
  15. Bennion D, Jensen T, Walther C, Hamblin J, Wallmann A, Couch J, Blickenstaff J, Castle M, Dean L, Beckstead S, Merrill C, Muir C, St Pierre T, Williams B, Daniel S, Edwards JG (2011) Transient receptor potential vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system. Neuropharmacology 61:730–738PubMedCrossRefGoogle Scholar
  16. Berg AP, Sen N, Bayliss DA (2007) TRPC3/C7 and Slo2.1 are molecular targets for metabotropic glutamate receptor signaling in rat striatal cholinegrgic interneurons. J Neurosci 27:8845–8856PubMedCrossRefGoogle Scholar
  17. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE (2004) Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol 6:709–720PubMedCrossRefGoogle Scholar
  18. Carreno O, Corominas R, Fernandez-Morales J, Camina M, Sobrido MJ, Fernandez-Fernandez JM, Pozo-Rosich P, Cormand B, Macaya A (2012) SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population. Am J Med Genet B Neuropsychiatr Genet 159B:94–103PubMedCrossRefGoogle Scholar
  19. Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O’Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI (2011) Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci 31:5067–5077PubMedCrossRefGoogle Scholar
  20. Chahl LA (2007) TRP’s: links to schizophrenia? Biochim Biophys Acta 1772:968–977PubMedCrossRefGoogle Scholar
  21. Chávez AE, Chiu CQ, Castillo PE (2010) TRPV1 activation by endogenous anandamide triggers postsynaptic LTD in dentate gyrus. Nat Neurosci 13:1511–1518PubMedCrossRefGoogle Scholar
  22. Cho JH, Jeong MY, Choi IS, Lee HJ, Jang IS (2012) TRPA1-like channels enhance glycinergic transmission in medullary dorsal horn neurons. J Neurochem 122(4):691–701PubMedCrossRefGoogle Scholar
  23. Chung YH, Kim D, Moon NJ, Oh CS, Lee E, Shin DH, Kim SS, Lee WB, Lee JY, Cha CI (2007) Immunohistochemical study on the distribution of canonical transient receptor potential channels in rat basal ganglia. Neurosci Lett 422:18–23PubMedCrossRefGoogle Scholar
  24. Chung KK, Freestone PS, Lipski JL (2011) The expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. J Neurophysiol 106:2865–2875PubMedCrossRefGoogle Scholar
  25. Clarke LE, Attwell D (2011) An astrocyte TRP switch for inhibition. Nat Neurosci 15:3–4PubMedCrossRefGoogle Scholar
  26. Cook NL, Van Den Heuvel C, Vink R (2009) Are the transient receptor potential melastatin (TRPM) channels important in magnesium homeostasis following traumatic brain injury? Magnes Res 22:225–234PubMedGoogle Scholar
  27. Coombes E, Jiang J, Chu XP, Inoue K, Seeds J, Branigan D, Simon RP, Xiong ZG (2011) Pathophysiological relevant levels of hydrogen peroxide induces glutamate-independent neurodegeneration that involves activation of TRPM7 channels. Antioxid Redox Signal 14:1815–1827PubMedCrossRefGoogle Scholar
  28. Cristino L, de Petrocellis L, Pryce G, Baker D, Guglielmotti V, Di Marzo V (2006) Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain. Neuroscience 139:1405–1415PubMedCrossRefGoogle Scholar
  29. Crowder EA, Saha MS, Pace RW, Zhang H, Prestwich GD, Del Negro CA (2007) Phosphatidylinositol 4,5-biphosphate regulates inspiratory burst activity in the neonatal mouse preBotzinger complex. J Physiol 582:1047–1058PubMedCrossRefGoogle Scholar
  30. Cucchiaroni ML, Viscomi MT, Bernardi G, Molinari M, Guatteo E, Mercuri NB (2010) Metabotropic glutamate receptor 1 mediates the electrophysiological and toxic actions of the cycad derivative beta-N-Methylamino-L-alanine on substantia nigra pars compacta DAergic neurons. J Neurosci 30:5176–5188PubMedCrossRefGoogle Scholar
  31. Czondor K, Ellwanger K, Fuchs YF, Lutz S, Gulyas M, Mansuy IM, Hausser A, Pfizenmaier K, Schlett K (2009) Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Mol Biol Cell 20:2108–2120PubMedCrossRefGoogle Scholar
  32. Damann N, Voets T, Nilius B (2008) TRPs in our senses. Curr Biol 18:R880–R889PubMedCrossRefGoogle Scholar
  33. Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL (2005) Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation. J Neurosci 25:446–453, United StatesPubMedCrossRefGoogle Scholar
  34. Dong XP, Wang X, Xu H (2010) TRP channels of intracellular membranes. J Neurochem 113:313–328PubMedCrossRefGoogle Scholar
  35. Du J, Yang X, Zhang L, Zeng YM (2009) Expression of TRPM8 in the distal cerebrospinal fluid-contacting neurons in the brain mesencephalon of rats. Cerebrospinal Fluid Res 6:3PubMedCrossRefGoogle Scholar
  36. Egorov AV, Hamam BN, Fransen E, Hasselmo ME, Alonso AA (2002) Graded persistent activity in entorhinal cortex neurons. Nature 420:173–178PubMedCrossRefGoogle Scholar
  37. El-Hassar L, Hagenston AM, Bertetto D'Angelo L, Yeckel M (2011) MGluRs regulate hippocampal CA1 pyramidal neuron excitability via Ca2+ wave-dependent activation of SK and TRPC channels. J Physiol 589:3211–3229PubMedCrossRefGoogle Scholar
  38. Feldman JL, Del Negro CA (2006) Looking for inspiration: new perspectives on respiratory rhythm. Nat Rev Neurosci 7:232–242, EnglandPubMedCrossRefGoogle Scholar
  39. Fernandez-Ruiz J, Hernandez M, Ramos JA (2010) Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders. CNS Neurosci Ther 16:e72–e91PubMedCrossRefGoogle Scholar
  40. Fonfria E, Murdock PR, Cusdin FS, Benham CD, Kelsell RE, McNulty S (2006) Tissue distribution profiles of the human TRPM cation channel family. J Recept Signal Transduct Res 26:159–178PubMedCrossRefGoogle Scholar
  41. Fowler MA, Sidiropoulou K, Ozkan ED, Phillips CW, Cooper DC (2007) Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PLoS One 2:e573PubMedCrossRefGoogle Scholar
  42. Freestone PS, Chung KK, Guatteo E, Mercuri NB, Nicholson LF, Lipski J (2009) Acute action of rotenone on nigral dopaminergic neurons – involvement of reactive oxygen species and disruption of Ca homeostasis. Eur J Neurosci 30:849–859CrossRefGoogle Scholar
  43. Fu M, Xie Z, Zuo H (2009) TRPV1: a potential target for antiepileptogenesis. Med Hypotheses 73:100–102PubMedCrossRefGoogle Scholar
  44. Gasperini RJ, Choi-Lundberg D, Thompson MJ, Mitchell CB, Foa L (2009) Homer regulates calcium signalling in growth cone turning. Neural Dev 4:29PubMedCrossRefGoogle Scholar
  45. Gao YQ, Gao H, Zhou ZY, Lu SD, Sun FY (2004) Expression of transient receptor potential channel 4 in striatum and hippocampus of rats is increased after focal cerebral ischemia. Sheng li xue bao: Acta physiologica Sinica 56:153–157PubMedGoogle Scholar
  46. Genro BP, de Oliveira Alvares L, Quillfeldt JA (2012) Role of TRPV1 in consolidation of fear memories depends on the averseness of the conditioning procedure. Neurobiol Learn Mem 97:355–360PubMedCrossRefGoogle Scholar
  47. Giampa C, Demarch Z, Patassini S, Bernardi G, Fusco FR (2007) Immunohistochemical localization of TRPC6 in the rat substantia nigra. Neurosci Lett 424:170–174PubMedCrossRefGoogle Scholar
  48. Gibon J, Deloulme JC, Chevallier T, Ladeveze E, Abrous DN, Bouron A (2012) The antidepressant hyperforin increases the phosphorylation of CREB and the expression of TrkB in a tissue-specific manner. Int J Neuropsychopharmacol 1–10Google Scholar
  49. Gibson HE, Edwards JG, Page RS, Van Hook MJ, Kauer JA (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 57:746–759PubMedCrossRefGoogle Scholar
  50. Gokce O, Runne H, Kuhn A, Luthi-Carter R (2009) Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation. PLoS One 4:e5292PubMedCrossRefGoogle Scholar
  51. Goswami C, Hucho T (2007) TRPV1 expression-dependent initiation and regulation of filopodia. J Neurochem 103:1319–1333PubMedCrossRefGoogle Scholar
  52. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (2003) TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci 6:837–845PubMedCrossRefGoogle Scholar
  53. Griffith TN, Varela-Nallar L, Dinamarca MC, Inestrosa NC (2010) Neurobiological effects of hyperforin and its potential in Alzheimer’s disease therapy. Curr Med Chem 17:391–406PubMedCrossRefGoogle Scholar
  54. Grueter BA, Brasnjo G, Malenka RC (2010) Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens. Nat Neurosci 13:1519–1525PubMedCrossRefGoogle Scholar
  55. Guatteo E, Chung KK, Bowala TK, Bernardi G, Mercuri NB, Lipski J (2005) Temperature sensitivity of dopaminergic neurons of the substantia nigra pars compacta: involvement of transient receptor potential channels. J Neurophysiol 94:3069–3080PubMedCrossRefGoogle Scholar
  56. Guler AD, Lee H, Iida T, Shimizu I, Tominaga M, Caterina M (2002) Heat-evoked activation of the ion channel, TRPV4. J Neurosci 22:6408–6414PubMedGoogle Scholar
  57. Hara K, Kokubo Y, Ishiura H, Fukuda Y, Miyashita A, Kuwano R, Sasaki R, Goto J, Nishizawa M, Kuzuhara S, Tsuji S (2010) TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan. Am J Med Genet B Neuropsychiatr Genet 153B:310–313PubMedGoogle Scholar
  58. Hartmann, J. & Konnerth, A. (2008). Mechanisms of metabotropic glutamate receptor-mediated synaptic signaling in cerebellar Purkinje cells. Acta Physiol (Oxf)Google Scholar
  59. Hartmann J, Dragicevic E, Adelsberger H, Henning HA, Sumser M, Abramowitz J, Blum R, Dietrich A, Freichel M, Flockerzi V, Birnbaumer L, Konnerth A (2008) TRPC3 channels are required for synaptic transmission and motor coordination. Neuron 59:392–398PubMedCrossRefGoogle Scholar
  60. Hartmann J, Henning HA, Konnerth A (2011) mGluR1/TRPC3-mediated synaptic transmission and calcium signaling in mammalian central neurons. Cold Spring Harbor Perspect Biol 3:a00676CrossRefGoogle Scholar
  61. Harteneck C (2003) Proteins modulating TRP channel function. Cell Calcium 33:303–310PubMedCrossRefGoogle Scholar
  62. Henle SJ, Wang G, Liang E, Wu M, Poo MM, Henley JR (2011) Asymmetric PI(3,4,5)P3 and Akt signaling mediates chemotaxis of axonal growth cones. J Neurosci 31:7016–7027PubMedCrossRefGoogle Scholar
  63. Henley J, Poo MM (2004) Guiding neuronal growth cones using Ca2+ signals. Trends Cell Biol 14:320–330, EnglandPubMedCrossRefGoogle Scholar
  64. Henley JR, Huang KH, Wang D, Poo MM (2004) Calcium mediates bidirectional growth cone turning induced by myelin-associated glycoprotein. Neuron 44:909–916, United StatesPubMedCrossRefGoogle Scholar
  65. Heo DK, Chung WY, Park HW, Yuan JP, Lee MG, Kim JY (2012) Opposite regulatory effects of TRPC1 and TRPC5 on neurite outgrowth in PC12 cells. Cell Signal 24:899–906PubMedCrossRefGoogle Scholar
  66. Hermosura MC, Garruto RM (2007) TRPM7 and TRPM2-candidate susceptibility genes for western pacific ALS and PD? Biochim Biophys Acta 1772:822–835PubMedCrossRefGoogle Scholar
  67. Hermosura MC, Nayakanti H, Dorovkov MV, Calderon FR, Ryazanov AG, Haymer DS, Garruto RM (2005) A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. Proc Natl Acad Sci USA 102:11510–11515PubMedCrossRefGoogle Scholar
  68. Hermosura M, Cui AM, Go G, Davenport B, Shetler C, Heizer J, Schmitz C, Mocz G, Garruto R, Perraud A-L (2008) Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proc Natl Acad Sci (USA) 105:18029–18034CrossRefGoogle Scholar
  69. Hofmann T, Chubanov V, Gudermann T, Montell C (2003) TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol 13:1153–1158PubMedCrossRefGoogle Scholar
  70. Holland S, Scholich K (2011) Regulation of neuronal functions by the E3-ubiquitinligase protein associated with MYC (MYCBP2). Commun Integr Biol 4:513–515PubMedGoogle Scholar
  71. Hong K, Nishiyama M, Henley J, Tessier-Lavigne M, Poo M (2000) Calcium signalling in the guidance of nerve growth by netrin-1. Nature 403:93–98PubMedCrossRefGoogle Scholar
  72. Hu J, Choo HJ, Ma SX (2012) Infrared heat treatment reduces food intake and modifies expressions of TRPV3-POMC in the dorsal medulla of obesity prone rats. Int J Hyperthermia 27:708–716CrossRefGoogle Scholar
  73. Hutchins BI, Li L, Kalil K (2010) Wnt/calcium signaling mediates axon growth and guidance in the developing corpus callosum. Dev Neurobiol 71:269–283CrossRefGoogle Scholar
  74. Iida T, Shimizu I, Nealen ML, Campbell A, Caterina M (2005) Attenuated fever response in mice lacking TRPV1. Neurosci Lett 378:28–33PubMedCrossRefGoogle Scholar
  75. Jang Y, Jung J, Kim H, Oh J, Jeon JH, Jung S, Kim KT, Cho H, Yang DJ, Kim SM, Kim IB, Song MR, Oh U (2012) Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. J Biol Chem 287:6014–6024PubMedCrossRefGoogle Scholar
  76. Jia Y, Zhou J, Tai Y, Wang Y (2007) TRPC channels promote cerebellar granule neuron survival. Nat Neurosci 10:559–567PubMedCrossRefGoogle Scholar
  77. Jiang X, Newell EW, Schlichter LC (2003) Regulation of a TRPM7-like current in rat brain microglia. J Biol Chem 278:42867–42876PubMedCrossRefGoogle Scholar
  78. Kaczmarek LK (2006) Non-conducting functions of voltage-gated ion channels. Nat Rev Neurosci 7:761–771PubMedCrossRefGoogle Scholar
  79. Kaczmarek JS, Riccio A, Clapham DE (2012) Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proc Natl Acad Sci USA 109:7888–7892PubMedCrossRefGoogle Scholar
  80. Kauer JA, Gibson HE (2009) Hot flash: TRPV channels in the brain. Trends Neurosci 32:215–224PubMedCrossRefGoogle Scholar
  81. Kiselyov K, Yamaguchi S, Lyons CW, Muallem S (2010) Aberrant Ca(2+) handling in lysosomal storage disorders. Cell Calcium 47:103–111PubMedCrossRefGoogle Scholar
  82. Kiselyov K, Colletti GA, Terwilliger A, Ketchum K, Lyons CW, Quinn J, Muallem S (2011) TRPML: transporters of metals in lysosomes essential for cell survival? Cell Calcium 50:288–294PubMedCrossRefGoogle Scholar
  83. Koch M, Kreutz S, Bottger C, Grabiec U, Ghadban C, Korf HW, Dehghani F (2011) The cannabinoid WIN 55,212-2-mediated protection of dentate gyrus granule cells is driven by CB1 receptors and modulated by TRPA1 and Cav 2.2 channels. Hippocampus 21:554–564PubMedCrossRefGoogle Scholar
  84. Kumar S, Chakraborty S, Barbosa C, Brustovetsky T, Brustovetsky N, Obukhov AG (2012) Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: the role of TRPC channels. J Cell Physiol 227:1408–1419PubMedCrossRefGoogle Scholar
  85. Kunert-Keil C, Bisping F, Kruger J, Brinkmeier H (2006) Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains. BMC Genomics 7:159PubMedCrossRefGoogle Scholar
  86. Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002) TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell 109:397–407PubMedCrossRefGoogle Scholar
  87. Lee N, Chen J, Sun L, Wu S, Gray KR, Rich A, Huang M, Lin JH, Feder JN, Janovitz EB, Levesque PC, Blanar MA (2003) Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3). J Biol Chem 278:20890–20897PubMedCrossRefGoogle Scholar
  88. Lee KH, Cho JH, Choi IS, Park HM, Lee MG, Choi BJ, Jang IS (2010) Pregnenolone sulfate enhances spontaneous glutamate release by inducing presynaptic Ca2+−induced Ca2+ release. Neuroscience 171:106–116PubMedCrossRefGoogle Scholar
  89. Leuner K, Kazanski V, Muller M, Essin K, Henke B, Gollasch M, Harteneck C, Muller WE (2007) Hyperforin – a key constituent of St. John’s wort specifically activates TRPC6 channels. FASEB J 21:4101–4111PubMedCrossRefGoogle Scholar
  90. Li Y, Jia YC, Cui K, Li N, Zheng ZY, Wang YZ, Yuan XB (2005) Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Nature 434:894–898PubMedCrossRefGoogle Scholar
  91. Li L, Hutchins BI, Kalil K (2010) Wnt5a induces simultaneous cortical axon outgrowth and repulsive turning through distinct signaling mechanisms. Sci Signal 3:pt2PubMedCrossRefGoogle Scholar
  92. Li M, Chen C, Zhou Z, Xu S, Yu Z (2012) A TRPC1-mediated increase in store-operated Ca(2+) entry is required for the proliferation of adult hippocampal neural progenitor cells. Cell Calcium 51:486–496PubMedCrossRefGoogle Scholar
  93. Liapi A, Wood JN (2005) Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Eur J Neurosci 22:825–834PubMedCrossRefGoogle Scholar
  94. Lin W, Margolskee R, Donnert G, Hell SW, Restrepo D (2007) Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals. Proc Natl Acad Sci U S A 104:2471–2476PubMedCrossRefGoogle Scholar
  95. Lipski J, Park TI, Li D, Lee SC, Trevarton AJ, Chung KK, Freestone PS, Bai JZ (2006) Involvement of TRP-like channels in the acute ischemic response of hippocampal CA1 neurons in brain slices. Brain Res 1077:187–199PubMedCrossRefGoogle Scholar
  96. Lowry CA, Lightman SL, Nutt DJ (2009) That warm fuzzy feeling: brain serotonergic neurons and the regulation of emotion. J Psychopharmacol 23:392–400PubMedCrossRefGoogle Scholar
  97. Manna SS, Umathe SN (2011) Transient receptor potential vanilloid 1 channels modulate the anxiolytic effect of diazepam. Brain Res 1425:75–82PubMedCrossRefGoogle Scholar
  98. Marsch R, Foeller E, Rammes G, Bunck M, Kossl M, Holsboer F, Zieglgansberger W, Landgraf R, Lutz B, Wotjak CT (2007) Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J Neurosci 27:832–839PubMedCrossRefGoogle Scholar
  99. Martorana A, Giampa C, DeMarch Z, Viscomi MT, Patassini S, Sancesario G, Bernardi G, Fusco FR (2006) Distribution of TRPC1 receptors in dendrites of rat substantia nigra: a confocal and electron microscopy study. Eur J Neurosci 24:732–738PubMedCrossRefGoogle Scholar
  100. McGurk JS, Shim S, Kim JY, Wen Z, Song H, Ming GL (2011) Postsynaptic TRPC1 function contributes to BDNF-induced synaptic potentiation at the developing neuromuscular junction. J Neurosci 31:14754–14762PubMedCrossRefGoogle Scholar
  101. Meriaux C, Arafah K, Tasiemski A, Wisztorski M, Bruand J, Boidin-Wichlacz C, Desmons A, Debois D, Laprevote O, Brunelle A, Gaasterland T, Macagno E, Fournier I, Salzet M (2011) Multiple changes in peptide and lipid expression associated with regeneration in the nervous system of the medicinal leech. PLoS One 6:e18359PubMedCrossRefGoogle Scholar
  102. Mezey E, Toth ZE, Cortright DN, Arzubi MK, Krause JE, Elde R, Guo A, Blumberg PM, Szallasi A (2000) Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc Natl Acad Sci USA 97:3655–3660PubMedCrossRefGoogle Scholar
  103. Miedel MT, Rbaibi Y, Guerriero CJ, Colletti G, Weixel KM, Weisz OA, Kiselyov K (2008) Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis. J Exp Med 205:1477–1490PubMedCrossRefGoogle Scholar
  104. Mironov SL (2008) Metabotropic glutamate receptors activate dendritic calcium waves and TRPM channels which drive rhythmic respiratory patterns in mice. J Physiol 586:2277–2291PubMedCrossRefGoogle Scholar
  105. Mironov SL, Skorova EY (2011) Stimulation of bursting in pre-Botzinger neurons by Epac through calcium release and modulation of TRPM4 and K-ATP channels. J Neurochem 117:295–308PubMedCrossRefGoogle Scholar
  106. Mitchell CB, Gasperini RJ, Small DH, Foa L (2012) STIM1 is necessary for store operated calcium entry in turning growth cones. J Neurochem 122:1155–1166PubMedCrossRefGoogle Scholar
  107. Mitsumura K, Hosoi N, Furuya N, Hirai H (2011) Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice. J Physiol 589:3191–3209PubMedCrossRefGoogle Scholar
  108. Moran MM, Xu H, Clapham DE (2004) TRP ion channels in the nervous system. Curr Opin Neurobiol 14:362–369PubMedCrossRefGoogle Scholar
  109. Moreira FA, Aguiar DC, Terzian AL, Guimaraes FS, Wotjak CT (2011) Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety-two sides of one coin? Neuroscience 204:186–192PubMedCrossRefGoogle Scholar
  110. Mori F, Ribolsi M, Kusayanagi H, Monteleone F, Mantovani V, Buttari F, Marasco E, Bernardi G, Maccarrone M, Centonze D (2012) TRPV1 channels regulate cortical excitability in humans. J Neurosci 32:873–879PubMedCrossRefGoogle Scholar
  111. Morley JE, Banks WA (1998) Lipids and cognition. J Alzheimers Dis 20:737–747Google Scholar
  112. Moussaieff A, Rimmerman N, Bregman T, Straiker A, Felder CC, Shoham S, Kashman Y, Huang SM, Lee H, Shohami E, Mackie K, Caterina MJ, Walker JM, Fride E, Mechoulam R (2008) Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J 22:3024–3034PubMedCrossRefGoogle Scholar
  113. Moussaieff A, Yu J, Zhu H, Gattoni-Celli S, Shohami E, Kindy MS (2012) Protective effects of incensole acetate on cerebral ischemic injury. Brain Res 1443:89–97PubMedCrossRefGoogle Scholar
  114. Mrejeru A, Wei A, Ramirez JM (2011) CAN currents are involved in generation of tonic and bursting activity in dopamine neurons of the substantia nigra pars compacta. J Physiol 589:2497–2514PubMedCrossRefGoogle Scholar
  115. Musella A, De Chiara V, Rossi S, Prosperetti C, Bernardi G, Maccarrone M, Centonze D (2008) TRPV1 channels facilitate glutamate transmission in the striatum. Mol Cell Neurosci 40:89–97PubMedCrossRefGoogle Scholar
  116. Musella A, De Chiara V, Rossi S, Cavasinni F, Castelli M, Cantarella C, Mataluni G, Bernardi G, Centonze D (2010) Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum. Neuroscience 167:864–871PubMedCrossRefGoogle Scholar
  117. Narayanan KL, Irmady K, Subramaniam S, Unsicker K, von Bohlen und Halbach O (2008) Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death. Neurosci Lett 446:117–122PubMedCrossRefGoogle Scholar
  118. Nelson C, Glitsch MD (2012) Lack of kinase regulation of canonical transient receptor Potential (TRPC) 3 dependent currents in rat cerebellar Purkinje cells. J Biol Chem 287:6326–6335PubMedCrossRefGoogle Scholar
  119. Nilius B, Owsianik G (2011) The transient receptor potential family of ion channels. Genome Biol 12:218–229PubMedCrossRefGoogle Scholar
  120. Nishiyama M, Hoshino A, Tsai L, Henley JR, Goshima Y, Tessier-Lavigne M, Poo MM, Hong K (2003) Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning. Nature 423:990–995, EnglandPubMedCrossRefGoogle Scholar
  121. Olah ME, Jackson MF, Li H, Perez Y, Sun HS, Kiyonaka S, Mori Y, Tymianski M, Macdonald JF (2009) Ca2+−dependent induction of TRPM2 currents in hippocampal neurons. J Physiol 587:965–979PubMedCrossRefGoogle Scholar
  122. Pace RW, Mackay DD, Feldman JL, Del Negro CA (2007) Role of persistent sodium current in mouse preBotzinger complex neurons and respiratory rhythm generation. J Physiol 580:485–496PubMedCrossRefGoogle Scholar
  123. Paez PM, Fulton D, Spreuer V, Handley V, Campagnoni AT (2011) Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene. J Neurosci 31:3625–3637PubMedCrossRefGoogle Scholar
  124. Petersson ME, Yoshida M, Fransen EA (2011) Low-frequency summation of synaptically activated transient receptor potential channel-mediated depolarizations. Eur J Neurosci 34:578–593PubMedCrossRefGoogle Scholar
  125. Philipp S, Hambrecht J, Braslavski L, Schroth G, Freichel M, Murakami M, Cavalie A, Flockerzi V (1998) A novel capacitative calcium entry channel expressed in excitable cells. EMBO J 17:4274–4282PubMedCrossRefGoogle Scholar
  126. Poduslo SE, Huang R, Huang J (2008) The frequency of the TRPC4AP haplotype in Alzheimer’s patients. Neurosci Lett 450:344–346PubMedCrossRefGoogle Scholar
  127. Poduslo SE, Huang R, Huang J, Smith S (2009) Genome screen of late-onset Alzheimer’s extended pedigrees identifies TRPC4AP by haplotype analysis. Am J Med Genet B Neuropsychiatr Genet 150B:50–55PubMedCrossRefGoogle Scholar
  128. Pressler RT, Strowbridge BW (2006) Blanes cells mediate persistent feedforward inhibition onto granule cells in the olfactory bulb. Neuron 49:889–904, United StatesPubMedCrossRefGoogle Scholar
  129. Puertollano R, Kiselyov K (2009) TRPMLs: in sickness and in health. Am J Physiol Renal Physiol 296:F1245–F1254PubMedCrossRefGoogle Scholar
  130. Puram SV, Riccio A, Koirala S, Ikeuchi Y, Kim AH, Corfas G, Bonni A (2011) A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain. Genes Dev 25:2659–2673PubMedCrossRefGoogle Scholar
  131. Qiu J, Fang Y, Bosch MA, Ronnekleiv OK, Kelly MJ (2011) Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels. Endocrinology 152:1503–1514PubMedCrossRefGoogle Scholar
  132. Reuss S, Disque-Kaiser U, Binzen U, Greffrath W, Peschke E (2010) ‘TRPing’ synaptic ribbon function in the rat pineal gland: neuroendocrine regulation involves the capsaicin receptor TRPV1. Neuroendocrinology 92:133–142PubMedCrossRefGoogle Scholar
  133. Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD, Pangalos MN (2002) mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res 109:95–104PubMedCrossRefGoogle Scholar
  134. Roedding AS, Gao AF, Wu AM, Li PP, Kish SJ, Warsh JJ (2009) TRPC3 protein is expressed across the lifespan in human prefrontal cortex and cerebellum. Brain Res 1260:1–6PubMedCrossRefGoogle Scholar
  135. Roedding AS, Gao AF, Au-Yeung W, Scarcelli T, Li PP, Warsh JJ (2012) Effect of oxidative stress on TRPM2 and TRPC3 channels in B lymphoblast cells in bipolar disorder. Bipolar Disord 14:151–161PubMedCrossRefGoogle Scholar
  136. Romero JR, Ridker PM, Zee RY (2009) Gene variation of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7), and risk of incident ischemic stroke. Prospective, nested, case–control study. Stroke 64:791–797Google Scholar
  137. Rubin JE, Hayes JA, Mendenhall JL, Del Negro CA (2009) Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations. Proc Natl Acad Sci USA 106:2939–2944PubMedCrossRefGoogle Scholar
  138. Schiller Y (2004) Activation of a calcium-activated cation current during epileptiform discharges and its possible role in sustaining seizure-like events in neocortical slices. J Neurophysiol 92:862–872PubMedCrossRefGoogle Scholar
  139. Shen D, Wang X, Li X, Zhang X, Yao Z, Dibble S, Dong XP, Yu T, Lieberman AP, Showalter HD, Xu H (2012) Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nat Commun 3:731PubMedCrossRefGoogle Scholar
  140. Shibasaki K, Suzuki M, Mizuno A, Tominaga M (2007) Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4. J Neurosci 27:1566–1575PubMedCrossRefGoogle Scholar
  141. Shibasaki K, Murayama N, Ono K, Ishizaki Y, Tominaga M (2010) TRPV2 Enhances Axon Outgrowth through Its Activation by Membrane Stretch in Developing Sensory and Motor Neurons. J Neurosci 30:4601–4612PubMedCrossRefGoogle Scholar
  142. Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS (2011) TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci 15:70–80PubMedCrossRefGoogle Scholar
  143. Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS (2012) TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci 15:70–80CrossRefGoogle Scholar
  144. Shim S, Yuan JP, Kim JY, Zeng W, Huang G, Milshteyn A, Kern D, Muallem S, Ming G-L, Worley PF (2009) Peptidyl-Prolyl Isomerase FKBP52 Controls Chemotropic Guidance of Neuronal Growth Cones via Regulation of TRPC1 Channel Opening. Neuron 64:471–483PubMedCrossRefGoogle Scholar
  145. Slaugenhaupt SA (2002) The molecular basis of mucolipidosis type IV. Curr Mol Med 2:445–450PubMedCrossRefGoogle Scholar
  146. Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK (2011) Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels. Neuron 71:488–497PubMedCrossRefGoogle Scholar
  147. Sossin WS, Barker PA (2007) Something old, something new: BDNF-induced neuron survival requires TRPC channel function. Nat Neurosci 10:537–538PubMedCrossRefGoogle Scholar
  148. Stawicki TM, Zhou K, Yochem J, Chen L, Jin Y (2011) TRPM Channels Modulate Epileptic-like Convulsions via Systemic Ion Homeostasis. Curr Biol. 21:883–888Google Scholar
  149. Stokes A, Wakano C, Koblan-Huberson M, Adra CN, Fleig A, Turner H (2006) TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. Cell Signal 18:1584–1594PubMedCrossRefGoogle Scholar
  150. Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645–655PubMedCrossRefGoogle Scholar
  151. Sun HS, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, Macdonald JF, Tymianski M (2009) Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nat Neurosci 12:1300–1307PubMedCrossRefGoogle Scholar
  152. Sylvester JB, Mwanjewe J, Grover AK (2001) Transient receptor potential protein mRNA expression in rat substantia nigra. Neurosci Lett 300:83–86PubMedCrossRefGoogle Scholar
  153. Tai Y, Feng S, Ge R, Du W, Zhang X, He Z, Wang Y (2008) TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci 121:2301–2307PubMedCrossRefGoogle Scholar
  154. Tai Y, Feng S, Du W, Wang Y (2009) Functional roles of TRPC channels in the developing brain. Pflugers Archiv: European journal of physiology 458:283–289PubMedCrossRefGoogle Scholar
  155. Talavera K, Nilius B, Voets T (2008) Neuronal TRP channels: thermometers, pathfinders and life-savers. Trends Neurosci 31:287–295PubMedCrossRefGoogle Scholar
  156. Tian SL, Jiang H, Zeng Y, Li LL, Shi J (2007) NGF-induced reduction of an outward-rectifying TRPM7-like current in rat CA1 hippocampal neurons. Neurosci Lett 419:93–98PubMedCrossRefGoogle Scholar
  157. Trebak M (2010) The puzzling role of TRPC3 channels in motor coordination. Pflugers Archiv: European journal of physiology 459:369–375PubMedCrossRefGoogle Scholar
  158. Toth A, Boczan J, Kedei N, Lizanecz E, Bagi Z, Papp Z, Edes I, Csiba L, Blumberg PM (2005) Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain. Brain Res Mol Brain Res 135:162–168PubMedCrossRefGoogle Scholar
  159. Tu P, Gibon J, Bouron A (2009a) The TRPC6 channel activator hyperforin induces the release of zinc and calcium from mitochondria. J Neurochem 112:204–213PubMedCrossRefGoogle Scholar
  160. Tu P, Kunert-Keil C, Lucke S, Brinkmeier H, Bouron A (2009b) Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons. J Neurochem 108:126–138PubMedCrossRefGoogle Scholar
  161. Uemura T, Kudoh J, Noda S, Kanba S, Shimizu N (2005) Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. Biochem Biophys Res Commun 328:1232–1243PubMedCrossRefGoogle Scholar
  162. Umathe SN, Manna SS, Jain NS (2012) Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor. Neuropharmacology 62:2024–2033PubMedCrossRefGoogle Scholar
  163. Venkatachalam K, Long AA, Elsaesser R, Nikolaeva D, Broadie K, Montell C (2008) Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells. Cell 135:838–851PubMedCrossRefGoogle Scholar
  164. Venugopal B, Mesires NT, Kennedy JC, Curcio-Morelli C, Laplante JM, Dice JF, Slaugenhaupt SA (2009) Chaperone-mediated autophagy is defective in mucolipidosis type IV. J Cell Physiol 219:344–353PubMedCrossRefGoogle Scholar
  165. Vriens J, Watanabe H, Janssens A, Droogmans G, Voets T, Nilius B (2004) Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci USA 101:396–401PubMedCrossRefGoogle Scholar
  166. Vriens J, Owsianik G, Hofmann T, Philipp SE, Stab J, Chen X, Benoit M, Xue F, Janssens A, Kerselaers S, Oberwinkler J, Vennekens R, Gudermann T, Nilius B, Voets T (2011) TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron 70:482–494PubMedCrossRefGoogle Scholar
  167. Wainwright A, Rutter AR, Seabrook GR, Reilly K, Oliver KR (2004) Discrete expression of TRPV2 within the hypothalamo-neurohypophysial system: implications for regulatory activity within the hypothalamic-pituitary-adrenal axis. J Comp Neurol 474:24–42PubMedCrossRefGoogle Scholar
  168. Wang GX, Poo MM (2005). Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones. Nature. 434:898–904Google Scholar
  169. Wang S, Zhang AP, Kurada L, Matsui T, Lei S (2011) Cholecystokinin Facilitates Neuronal Excitability in the Entorhinal Cortex via Activation of TRPC-like Channels. J Neurophysiol 106:1515–1524PubMedCrossRefGoogle Scholar
  170. Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, Nilius B (2003) Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424:434–438PubMedCrossRefGoogle Scholar
  171. Wei WL, Sun HS, Olah ME, Sun X, Czerwinska E, Czerwinski W, Mori Y, Orser BA, Xiong ZG, Jackson MF, Tymianski M, Macdonald JF (2007) TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci USA 104:16232–16328Google Scholar
  172. Wen Z, Han L, Bamburg JR, Shim S, Ming GL, Zheng JQ (2007) BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol 178:107–119PubMedCrossRefGoogle Scholar
  173. Williams KW, Sohn JW, Donato J Jr, Lee CE, Zhao JJ, Elmquist JK, Elias CF (2011) The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus. J Neurosci 31:13147–13156PubMedCrossRefGoogle Scholar
  174. Wodarczyk C, Rowe I, Chiaravalli M, Pema M, Qian F, Boletta A (2009) A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One 4:e7137PubMedCrossRefGoogle Scholar
  175. Wu ZZ, Chen SR, Pan HL (2005) Transient receptor potential vanilloid type 1 activation down-regulates voltage-gated calcium channels through calcium-dependent calcineurin in sensory neurons. J Biol Chem 280:18142–18151PubMedCrossRefGoogle Scholar
  176. Wu TT, Zhao ZJ, Xu C, Zhang LC (2011) Distribution of trpc6 in the cerebrospinal fluid-contacting nucleus of rat brain parenchyma and its expression in morphine dependence and withdrawal. Neurochem Res 36:2316–2321PubMedCrossRefGoogle Scholar
  177. Xie YF, Belrose JC, Lei G, Tymianski M, Mori Y, Macdonald JF, Jackson MF (2012) Dependence of NMDA/GSK3beta mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses. Mol Brain 4:44CrossRefGoogle Scholar
  178. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418:181–186PubMedCrossRefGoogle Scholar
  179. Xu C, Macciardi F, Li PP, Yoon IS, Cooke RG, Hughes B, Parikh SV, McIntyre RS, Kennedy JL, Warsh JJ (2006) Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 141:36–43Google Scholar
  180. Xu C, Li PP, Cooke RG, Parikh SV, Wang K, Kennedy JL, Warsh JJ (2009) TRPM2 variants and bipolar disorder risk: confirmation in a family-based association study. Bipolar Disord 11:1–10PubMedCrossRefGoogle Scholar
  181. Yan HD, Villalobos C, Andrade R (2009) TRPC channels mediate a muscarinic receptor-induced afterdepolarization in cerebral cortex. J Neurosci 29:10038–10046PubMedCrossRefGoogle Scholar
  182. Yin DM, Huang YH, Zhu YB, Wang Y (2008) Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus. J Neurosci 28:8832–8843PubMedCrossRefGoogle Scholar
  183. Yokoyama T, Ohbuchi T, Saito T, Sudo Y, Fujihara H, Minami K, Nagatomo T, Uezono Y, Ueta Y (2011) Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats. Eur J Pharmacol 655:31–37PubMedCrossRefGoogle Scholar
  184. Yoo JC, Yarishkin OV, Hwang EM, Kim E, Kim DG, Park N, Hong SG, Park JY (2010) Cloning and characterization of rat transient receptor potential-melastatin 4 (TRPM4). Biochem Biophys Res Commun 391:806–811PubMedCrossRefGoogle Scholar
  185. Zamudio-Bulcock PA, Valenzuela CF (2011) Pregnenolone sulfate increases glutamate release at neonatal climbing fiber-to-Purkinje cell synapses. Neuroscience 175:24–36PubMedCrossRefGoogle Scholar
  186. Zamudio-Bulcock PA, Everett J, Harteneck C, Valenzuela CF (2011) Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats. J Neurochem 119:474–485PubMedCrossRefGoogle Scholar
  187. Zechel S, Werner S, von Bohlen Und Halbach O (2007) Distribution of TRPC4 in developing and adult murine brain. Cell Tissue Res 328:651–656PubMedCrossRefGoogle Scholar
  188. Zhang J, Zhao F, Zhao Y, Wang J, Pei L, Sun N, Shi J (2011a) Hypoxia induces an increase in intracellular magnesium via TRPM7 channels in rat hippocampal neurons in vitro. J Biol Chem 286:20194–20207PubMedCrossRefGoogle Scholar
  189. Zhang Z, Reboreda A, Alonso A, Barker PA, Seguela P (2011b) TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex. Hippocampus 21:386–397PubMedCrossRefGoogle Scholar
  190. Zhou J, Du W, Zhou K, Tai Y, Yao H, Jia Y, Ding Y, Wang Y (2008) Critical role of TRPC6 channels in the formation of excitatory synapses. Nat Neurosci 11:741–743PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine (CMM)KU LeuvenLeuvenBelgium

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