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Transient Receptor Potential Cation Channels in Pancreatic β Cells

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Reviews of Physiology, Biochemistry and Pharmacology 161

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 161))

Abstract

There is now overwhelming evidence that TRP channels might play a significant role in the regulation of insulin release from pancreatic β cells, which is until now insufficiently recognized. TRP channels are abundantly expressed on β cells. The focus of this review will be on cation channels from the melastatin TRP ­subfamily. We will discuss how TRPM channels can influence Ca2+ signaling in β cells. Knock out models of TRPM2 and TRPM5, which show a pre-diabetic phenotype, will be illustrative for this purpose. Based on these insights, TRPM5 will be critically evaluated as a potential drug target for diabetes type II therapy, which has received currently a high interest of the pharmaceutical industry. In addition, an unexpected role of the TRP channel TRPM3 as a gatekeeper of zinc, which is required for insulin storage, will be considered. Finally, we will critically discuss the use of mouse models for the unraveling of basic mechanisms of insulin release. The study of the role of TRP channels in the regulation of insulin release is of wide interest for fundamental research, evaluation of molecular mechanisms of disease and exploration of novel drug targets for metabolic diseases.

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Authors and Affiliations

  1. Department of Molecular Cell Biology, Laboratory of Ion Channel Research, KU Leuven, Campus Gasthuisberg, Herestraat 49, bus 802, 3000, Leuven, Belgium

    Barbara Colsoul

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  1. Barbara Colsoul
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  2. Rudi Vennekens
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  3. Bernd Nilius
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Correspondence to Barbara Colsoul .

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Editors and Affiliations

  1. School of Medicine, Deptartment of Neurobiology, University of Pittsburgh, Fifth Avenue 3501, Pittsburgh, 15261, Pennsylvania, USA

    Susan G. Amara

  2. MPI für Biophysik, Max-von-Laue-Straße 3, Frankfurt, 60438, Germany

    Ernst Bamberg

  3. Institut für Physiologie I, Universität Bonn, Sigmund-Freud-Str. 25, Bonn, 53105, Germany

    Bernd K. Fleischmann

  4. Medizinische Fakultät, Walther-Straub-Institut für Pharmakologi, Ludwig-Maximilians-Universität München, Goethestr. 33, München, 80336, Germany

    Thomas Gudermann

  5. Abt. Neurobiologie, MPI für Biophysikalische Chemie, Am Faßberg 11, Göttingen, 37077, Germany

    Reinhard Jahn

  6. Center for Biomedical Engineering and Te, University of Maryland Baltimore, West Lombard Street 725, Baltimore, 21201, Maryland, USA

    William J. Lederer

  7. Inst. Zytobiologie und, Zytopathologie, Universität Marburg, Robert-Koch-Str. 5, Marburg, 35033, Germany

    Roland Lill

  8. Lab. Fysiologie, Katholieke Universiteit Leuven, Herestraat 49, Leuven, 3000, Belgium

    Bernd Nilius

  9. , Abteilung II, Max-Planck-Institut für Herz- und Lungen, Ludwigstr. 43, Bad Nauheim, 61231, Germany

    Stefan Offermanns

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Colsoul, B., Vennekens, R., Nilius, B. (2011). Transient Receptor Potential Cation Channels in Pancreatic β Cells. In: Amara, S., et al. Reviews of Physiology, Biochemistry and Pharmacology 161. Reviews of Physiology, Biochemistry and Pharmacology, vol 161. Springer, Berlin, Heidelberg. https://doi.org/10.1007/112_2011_2

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