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Parameters Influencing Lipase-Catalyzed Glycolipid Synthesis by (Trans-)Esterification Reaction

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Biosurfactants for the Biobased Economy

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 181))

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Abstract

Glycolipids are biodegradable, non-toxic surfactants with a wide range of applications. Enzymatic esterification or transesterification facilitated in reaction media of low water activity is a reaction strategy for the production of tailor-made glycolipids as a high structural diversity can be achieved. Organic solvents, ionic liquids, and deep eutectic solvents have been applied as reaction media. However, several challenges need to be addressed for efficient (trans-)esterification reactions, especially for the lipophilization of polar substrates. Therefore, crucial parameters in (trans-)esterification reactions in conventional and non-conventional media are discussed and compared in this review with a special focus on glycolipid synthesis.

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Acknowledgments

Conflicts of Interest: The authors declare no conflict of interest.

Author Contributions: Conceptualization, R.H.; writing – original draft preparation, R.H.; writing – review and editing, R.H., K.O and C.S.; supervision, C.S.; funding acquisition, C.S. All authors have read and agreed to the published version of the manuscript.

Funding: This work by R.H. was supported by the European Regional Development Fund and the Ministry of Science, Research and the Arts of the State of Baden-Württemberg within the research center ZAFH InSeL (Grant#32-7545.24-20/6/3). We gratefully thank the Open Access Publishing Fund of Karlsruhe Institute of Technology.

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  1. Institute of Process Engineering in Life Sciences II: Technical Biology, Karlsruhe Institute of Technology, Karlsruhe, Germany

    Rebecca Hollenbach, Katrin Ochsenreither & Christoph Syldatk

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  1. Rebecca Hollenbach
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  2. Katrin Ochsenreither
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  3. Christoph Syldatk
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Correspondence to Rebecca Hollenbach .

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  1. Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany

    Rudolf Hausmann

  2. Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany

    Marius Henkel

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Hollenbach, R., Ochsenreither, K., Syldatk, C. (2021). Parameters Influencing Lipase-Catalyzed Glycolipid Synthesis by (Trans-)Esterification Reaction. In: Hausmann, R., Henkel, M. (eds) Biosurfactants for the Biobased Economy. Advances in Biochemical Engineering/Biotechnology, vol 181. Springer, Cham. https://doi.org/10.1007/10_2021_173

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