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New Cell-Based Therapy Paradigm: Induction of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells into Pro-Inflammatory MSC1 and Anti-inflammatory MSC2 Phenotypes

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Mesenchymal Stem Cells - Basics and Clinical Application II

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 130))

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Abbreviations

ASC:

Adipose-derived multipotent stromal or mesenchymal stem cell

BM-MSC:

Bone marrow-derived multipotent stromal

COX:

Cyclooxygenase

CTL:

Cytotoxic T lymphocyte

ESCs:

Embryonic stem cells

HLA:

Human leukocyte antigen

HSCs:

Hematopoietic stem cells

IDO:

Indoleamine 2,3-dioxygenase

IFN:

Interferon

IL:

Interleukin

iNOS:

Inducible nitric-oxide synthase

iPSCs:

Induced pluripotent stem cells

LPS:

Lipopolysaccharide

MHC:

Major histocompatibility complex

MSC:

Multipotent stromal or mesenchymal stem cell

MSC1 :

Pro-inflammatory MSC phenotype

MSC2 :

Anti-inflammatory MSC phenotype

NF:

Nuclear factor

PGE-2:

Prostaglandin E2

TGF:

Transforming growth factor

TLR:

Toll-like receptor

TNF:

Tumor necrosis factor

Th1:

T Helper cell 1

Treg:

T Regulatory lymphocyte

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Acknowledgments

This work was supported by the National Institutes of Health grant 1P20RR20152-01, Department of Defense OC073102 Concept Award and research support from the Tulane Cancer Center and the Center for Stem Cell Research and Regenerative Medicine.

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Authors and Affiliations

  1. Center for Stem Cell Research and Regenerative Medicine, Tulane University, New Orleans, LA, USA

    Aline M. Betancourt

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Correspondence to Aline M. Betancourt .

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Editors and Affiliations

  1. Abt. für Plastische und Handchirurgie, Medizinische Hochschule Hannover, Hannover, Germany

    Birgit Weyand

  2. Integrated Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy

    Massimo Dominici

  3. Medizinische Hochschule Hannover, AG Biochemie und Tumorbiologie, Klinik für Frauenheilkunde und Geburtshilfe, Hannover, Germany

    Ralf Hass

  4. Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover, Niedersachsen, Germany

    Roland Jacobs

  5. Department für Biotechnologie, Universität für Bodenkultur, Wien, Austria

    Cornelia Kasper

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Betancourt, A.M. (2012). New Cell-Based Therapy Paradigm: Induction of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells into Pro-Inflammatory MSC1 and Anti-inflammatory MSC2 Phenotypes. In: Weyand, B., Dominici, M., Hass, R., Jacobs, R., Kasper, C. (eds) Mesenchymal Stem Cells - Basics and Clinical Application II. Advances in Biochemical Engineering/Biotechnology, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2012_141

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