Interaction of Cartilage and Ceramic Matrix

  • K. Wiegandt
  • C. Goepfert
  • R. Pörtner
  • R. JanssenEmail author
Part of the Advances in Biochemical Engineering Biotechnology book series (ABE, volume 126)


As subchondral bone is often affected during cartilage injuries, the aim of research is to generate osteochondral implants in vitro using tissue engineering techniques. These constructs consist of a cartilage layer grown on top of a bone phase. In clinical applications, phosphate ceramics have gained acceptance as bone substitute materials because of their great affinity to natural bone. Furthermore, the interaction between cartilage and the underlying bone equivalent is essential for the development and success of osteochondral implants. Here, the influence of a carrier containing hydroxyapatite on the quality of cartilage constructs generated in vitro is investigated. Attempts are made to explain the effects described, by considering chemical and physical properties of the biomaterial.


Bioceramics Cartilage Hydroxyapatite Osteochondral implants Surface structure 



We would like to thank Kerstin Michael, Ditte Siemesgelüss, Teresa Richter, Daniel Fritsch and Nadja Holstein for their excellent technical support. The project was kindly supported by DFG (PO 413/7-1) and by BWF-FHH (Tissue Engineering).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • K. Wiegandt
    • 1
  • C. Goepfert
    • 2
  • R. Pörtner
    • 2
  • R. Janssen
    • 1
    Email author
  1. 1.Institute of Advanced CeramicsHamburg University of TechnologyHamburgGermany
  2. 2.Institute of Bioprocess and Biosystems EngineeringHamburg University of TechnologyHamburgGermany

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