Abstract
Yeast was the first microorganism domesticated by mankind. Indeed, the production of bread and alcoholic beverages such as beer and wine dates from antiquity, even though the fact that the origin of alcoholic fermentation is a microorganism was not known until the nineteenth century. The use of starter cultures in yeast industries became a common practice after methods for the isolation of pure yeast strains were developed. Moreover, effort has been undertaken to improve these strains, first by classical genetic methods and later by genetic engineering. In general, yeast strain development has aimed at improving the velocity and efficiency of the respective production process and the quality of the final products. This review highlights the achievements in genetic engineering of Saccharomyces yeast strains applied in food and beverage industry.

- Baker's yeast
- Brewer's yeast
- Genetic engineering
- Metabolic engineering
- Saccharomyces cerevisiae
- Strain improvement
- Wine yeast
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References
Landry CR, Townsend JP, Hartl DL, Cavalieri D (2006) Mol Ecol 15:575
Legras JL, Merdinoglu D, Cornuet JM, Karst F (2007) Mol Ecol 16:2091
Fay JC, Benavides JA (2005) PLoS Genet 1:66
Barnett JA (1998) Yeast 14:1439
Barnett JA (2000) Yeast 16:755
Barnett JA (2003) Yeast 20:1015
Barnett JA (2003) Yeast 20:509
Barnett JA (2004) Yeast 21:1141
Barnett JA (2004) Yeast 21:703
Barnett JA (2007) Yeast 24:799
Barnett JA, Entian KD (2005) Yeast 22:835
Barnett JA, Lichtenthaler FW (2001) Yeast 18:363
Barnett JA, Robinow CF (2002) Yeast 19:745
Barnett JA, Robinow CF (2002) Yeast 19:151
Eddy AA, Barnett JA (2007) Yeast 24:1023
Schwann T (1837) Ann Phys Chem 41:184
Barnett JA (2003) Microbiology 149:557
Pasteur L (1860) Ann Chim Phys 58:323
Attfield PV, Bell PJL (2003) In: De Winde JH (ed) Functional genetics of industrial yeasts. Springer, Berlin Heidelberg New York, p 17
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG (1996) Science 274:546
Bailey JE (1991) Science 252:1668
Bailey JE, Birnbaum S, Galazzo JL, Khosla C, Shanks JV (1990) Ann NY Acad Sci 589:1
Sherman F (2002) Methods Enzymol 350:3
Mortimer RK, Johnston JR (1986) Genetics 113:35
Pretorius IS (2000) Yeast 16:675
Dequin S (2001) Appl Microbiol Biotechnol 56:577
Randez-Gil F, Sanz P, Prieto J (1999) TIBTECH 14:237
Klein CJ, Olsson L, Ronnow B, Mikkelsen JD, Nielsen J (1996) Appl Environ Microbiol 62:4441
Nevoigt E, Pilger R, Mast-Gerlach E, Schmidt U, Freihammer S, Eschenbrenner M, Garbe L, Stahl U (2002) FEMS Yeast Res 2:225
Kurtzman CP, Robnett CJ (2003) FEMS Yeast Res 3:417
Kurtzman CP (2003) FEMS Yeast Res 4:233
Barnett JA (1992) Yeast 8:1
Pretorius IS (2003) In: De Winde JH (ed) Functional genetics of industrial yeasts. Springer, Berlin Heidelberg New York, p 99
Hansen J, Kielland-Brandt MC (2003) In: De Winde JH (ed) Functional genetics of industrial yeasts. Springer, Heidelberg, p 143
Randez-Gil F, Aguilera J, Codon A, Rincon AM, Estruch F, Prieto JA (2003) In: de Winde JH (ed) Functional genetics of industrial yeasts (Topics in current genetics; 2). Springer, Berlin Heidelberg New York, p 58
SGD project. “Saccharomyces Genome Database” http://www.yeastgenome.org/ . Accessed 18 April 2008
Forschungszentrum für Umwelt und Gesundheit, GmbH “Comprehensive Yeast Genome Database” http://mips.gsf.de/genre/proj/yeast/ . Accessed 18 April 2008
Johnston JR, Baccari C, Mortimer RK (2000) Res Microbiol 151:583
Hansen E (1908) Comp Rend Trav Lab Carlsberg 7:179
Martini AV, Martini A (1987) Antonie Van Leeuwenhoek 53:77
Pedersen M (1986) Carlsberg Res Commun 51:163
Hansen J, Kielland-Brandt MC (1994) Gene 140:33
Pedersen M (1986) Carlsberg Res Commun 51:185
Tamai Y, Momma T, Yoshimoto H, Kaneko Y (1998) Yeast 14:923
Vaughan Martini A, Kurtzman C (1985) Int J Syst Bacteriol 35:508
Joubert R, Brignon P, Lehmann C, Monribot C, Gendre F, Boucherie H (2000) Yeast 16:511
Rainieri S, Kodama Y, Kaneko Y, Mikata K, Nakao Y, Ashikari T (2006) Appl Environ Microbiol 72:3968
James TC, Campbell S, Donnelly D, Bond U (2003) J Appl Microbiol 94:432
Olesen K, Felding T, Gjermansen C, Hansen J (2002) FEMS Yeast Res 2:563
Kodama Y, Kiellandt-Brandt M, Hansen J (2006) In: Sunnerhagen P, Piskur J (eds) Comperative genomics. Springer, Berlin Heidelberg New York, p 145
Nakao Y, Kodama Y, Nakamura N, Ito T, Hattori M, Shiba T, Ashikari T (2003) In: Proceedings of the 29th Congress of European Brewers Convention, Dublin, May 18–22
Olsson L, Nielsen J (2000) Enzyme Microb Technol 26:785
Young TW (1996) In: Priest FG, Campbell I (eds) Brewing microbiology. Chapman and Hall, London, p 13
Hammond JRM (1993) In: Rose AH, Harrison JS (eds) The yeasts, vol 5. Academic Press, New York, p 357
Treitel MA, Carlson M (1995) Proc Nat Acad Sci USA 92:3132
Klein CJ, Olsson L, Nielsen J (1998) Microbiology 144:13
Lutfiyya LL, Johnston M (1996) Mol Cell Biol 16:4790
Klein CJ, Rasmussen JJ, Ronnow B, Olsson L, Nielsen J (1999) J Biotechnol 68:197
Bro C, Knudsen S, Regenberg B, Olsson L, Nielsen J (2005) Appl Environ Microbiol 71:6465
Federoff HJ, Eccleshall TR, Marmur J (1983) J Bacteriol 156:301
Osinga KA, Beudeker RF, van der Plaat JB, Hollander JA (1988) EU Patent 0306107 A2
Olsson L, Larsen ME, Ronnow B, Mikkelsen JD, Nielsen J (1997) Appl Environ Microbiol 63:2366
Ostergaard S, Walloe KO, Gomes SG, Olsson L, Nielsen J (2001) FEMS Yeast Res 1:47
Chi ZM, Li JF, Wang XH, Yao SM (2004) Acta Biochim Biophys Sin (Shanghai) 36:443
Ronnow B, Olsson L, Nielsen J, Mikkelsen JD (1999) J Biotechnol 72:213
Day RE, Higgins VJ, Rogers PJ, Dawes IW (2002) Yeast 19:1015
Day RE, Rogers PJ, Dawes IW, Higgins VJ (2002) Appl Environ Microbiol 68:5326
Dietvorst J, Londesborough J, Steensma HY (2005) Yeast 22:775
Ostergaard S, Olsson L, Nielsen J (2000) Microbiol Mol Biol Rev 64:34
Hansen J, Kielland-Brandt M (1997) In: Zimmerman F, Entian K (eds) Yeast sugar metabolism, biochemistry, genetics, biotechnology and applications. Technomic, New York, p 503
Perry C, Meaden P (1988) J Inst Brew 94:64
Vakeria D, Hinchliffe E (1989) In: Proceedings of the 22nd Congress of European Brewers convention, Zürich, May 20–25
Yocum RR (1986) Proceedings of Bio Expo 86, Boston, April 29–May 1
Gopal C, Hammond J (1992) Proceedings of the 5th International Brewing Technology Conference, Harrogate, February 3–6
Lancashire W, Carter A, Howard J, Wilde R (1989) In: Proceedings of the 22nd Congress of European Brewers convention, Zürich, May 20–25
Hollenberg C, Strasser A (1990) Food Biotechnol 4:527
Pretorius IS, Bauer FF (2002) Trends Biotechnol 20:426
Liu Z, Zhang G, Liu S (2004) J Biosci Bioeng 98:414
Grundlli Moses SB, Cordero Otero RR, La Grange DC, Van Rensburg P, Pretorius IS (2002) Biotechnol Lett 24:651
Nieto A, Prieto JA, Sanz P (1999) Biotechnol Prog 15:459
Berghof K, Stahl U (1991) Bioengineering 7:27
Cantwell B, Brazil G, Hurley J, McConnell D (1985) In: Proceedings of the 20th Congress of European Brewers convention, Helsinki, June 3–6
Lancashire W, Wilde R (1987) In: Proceedings of the 21st Congress of European Brewers convention, Madrid, May 10–14
Enari T-M, Knowles J, Lehtinen U, Nikkola M, Penttilä M, Suihko M-L, Home S, Vilpola A (1987) In: Proceedings of the 21st Congress of European Brewers convention, Madrid, May 10–14
Hammond JRM (1996) In: Priest FG, Campbell I (eds) Brewing Microbiology. Chapman and Hall, London, p 43
Penttilä M, Suihko M-L, Lehtinen U, Nikkola M, Knowles J (1987) Curr Genet 12:413
Jackson E, Ballance G, Thomsen K (1986) Carlsberg Res Commun 51:445
Olsen O, Thomsen K (1989) Carlsberg Res Commun 54:29
Celestino KR, Cunha RB, Felix CR (2006) BMC Biochem 7:23
Perez-Gonzalez JA, Gonzalez R, Querol A, Sendra J, Ramon D (1993) Appl Environ Microbiol 59:2801
Van Rensburg P, Van Zyl W, Pretorius I (1994) Curr Genet 27:17
Louw C, La Grange D, Pretorius IS, Van Rensburg P (2006) J Biotechnol 125:447
Omura F, Fujita A, Miyajima K, Fukui N (2005) Biosci Biotechnol Biochem 69:1162
Boulton RB, Singleton VL, Bisson LF, Kunkee RE (1996) Principles and practices of winemaking. Chapman and Hall, New York
Salmon JM, Barre P (1998) Appl Environ Microbiol 64:3831
Stratford M (1989) Yeast 5:487
Stratford M (1992) Yeast 8:25
Claro FB, Rijsbrack K, Soares EV (2007) J Appl Microbiol 102:693
Sampermans S, Mortier J, Soares EV (2005) J Appl Microbiol 98:525
Soares EV, Vroman A (2003) J Appl Microbiol 95:325
Soares EV, Vroman A, Mortier J, Rijsbrack K, Mota M (2004) J Appl Microbiol 96:1117
Verstrepen KJ, Derdelinckx G, Verachtert H, Delvaux FR (2003) Appl Microbiol Biotechnol 61:197
Van der Aar P, Straver M, Teunissen A (1993) In: Proceedings of the 24th Congress of European Brewers convention, Oslo, June 8–10
Stratford M (1996) FEMS Microbial Lett 136:13
Stratford M, Assinder S (1991) Yeast 7:559
Dengis PB, Rouxhet PG (1997) Yeast 13:931
Masy CL, Henquinet A, Mestdagh MM (1992) Can J Microbiol 38:1298
He X, Guo W, Zhang B, Zhang P, Lian G, Wang C, Pan X (2002) Wei Sheng Wu Xue Bao 42:242
Teunissen A, Steensma H (1995) Yeast 11:1001
Bidard F, Blondin B, Dequin S, Vezinhet F, Barre P (1994) Curr Genet 25:196
Watari J, Takata Y, Ogawa M, Sahara H, Koshino S, Onnela ML, Airaksinen U, Jaatinen R, Penttila M, Keranen S (1994) Yeast 10:211
Watari J, Takata Y, Murakami J, Koshino S (1991) In: Proceedings of the 23rd Congress of European Brewers convention, Lisbon, May 13–15
Bony M, Bidart F, Camarasa C, Ansanay V, Dulau L, Barre P, Dequin S (1997) FEBS Lett 410:452
Guo B, Styles CA, Feng Q, Fink GR (2000) Proc Nat Acad Sci USA 97:12158
Riou C, Nicaud JM, Barre P, Gaillardin C (1997) Yeast 13:903
Verstrepen K, Bauer F, Michiels C, Derdelinckx G, Delvaux F, Pretorius I (1999) Symposium yeast physiology—a new era of opportunity. European Brewing convention, Monograph 28. Fachverlag Hans Carl, Nürnberg, p 30
Donalies UE, Stahl U (2001) Curr Genet 39:150
Sone H, Kondo K, Fujii T, Shimuzu F, Tanaka J, Inoue T (1987) In: Proceedings of the 21st Congress of European Brewers convention, Madrid, May 10–14
Sone H, Fujii T, Kondo K, Shimuzu F, Tanaka J, Inoue T (1988) Appl Environ Microbiol 54:38
Blomqvist K, Suihko ML, Knowles J, Penttila M (1991) Appl Environ Microbiol 57:2796
Fujii T, Kondo K, Shimizu F, Sone H, Tanaka J-I, Inoue T (1990) Appl Environ Microbiol 56:997
Goelling D, Stahl U (1988) Appl Environ Microbiol 54:1889
Yamano S, Tanaka J, Inoue T (1994) J Biotechnol 32:165
Suihko M-L, Penttila M, Sone H, Home S, Blomqvist K, Tanaka J, Inoue T, Knowles J (1989) In: Proceedings of the 22nd Congress of European Brewers convention, Zürich, May 20–25
Suihko ML, Blomqvist K, Penttila M, Gisler R, Knowles J (1990) J Biotechnol 14:285
Vogel J, Wackerbauer K, Stahl U (1995) ACS Symp Ser 605:160
Akada R (2002) J Biosci Bioeng 94:536
Takagi H, Matsui F, Kawaguchi A, Wu H, Shimoi H, Kubo Y (2007) J Biosci Bioeng 103:377
Wang ZY, He XP, Zhang BR (2007) Int J Food Microbiol 119:192
Aritomi K, Hirosawa I, Hoshida H, Shiigi M, Nishizawa Y, Kashiwagi S, Akada R (2004) Biosci Biotechnol Biochem 68:206
Hirosawa I, Aritomi K, Hoshida H, Kashiwagi S, Nishizawa Y, Akada R (2004) Appl Microbiol Biotechnol 65:68
Gjermansen C, Nilsson-Tillgren T, Petersen JG, Kielland-Brandt MC, Sigsgaard P, Holmberg S (1988) J Basic Microbiol 28:175
Falco SC, Dumas KS (1985) Genetics 109:21
Hammond JR (1995) Yeast 11:1613
Kiellandt-Brandt M, Gjermansen C, Nilsson-Tillgren T, Holmberg S (1989) In: Proceedings of the 22nd Congress of European Brewers convention, Zürich, May 20–25
Vakeria D, Box W, Hinchliffe E (1991) In: Proceedings of the 23rd Congress of European Brewers convention, Lisbon, May 13–15
Goossens E, Debourg A, Villanueba K, Masschelein C (1993) In: Proceedings of the 24th Congress of European Brewers convention, Oslo, June 8–10
Mithieux SM, Weiss AS (1995) Yeast 11:311
Villanueba K, Gossens E, Masschelein C (1990) J Am Soc Brew Chem 48:111
Goossens E, Debourg A, Villanueba K, Masschelein C (1991) In: Proceedings of the 23rd Congress of European Brewers convention, Lisbon, May 13–15
Goossens E, Dillemans M, Debourg A, Masschelein C (1987) In: Proceedings of the 21st Congress of European Brewers convention, Madrid, May 10–14
Korch C, Mountain H, Gyllang H, Winge H, Brehmer P (1991) In: Proceedings of the 23rd Congress of European Brewers convention, Lisbon, May 13–15
Donalies UE, Stahl U (2002) Yeast 19:475
Hansen J, Kielland-Brandt M (1996) Nat Biotechnol 14:1587
Hansen J, Kielland-Brandt MC (1996) J Biotechnol 50:75
Dufour J-P (1991) In: Proceedings of the 23rd Congress of European Brewers convention, Lisbon, May 13–15
Johannesen PF, Nyborg M, Hansen J (1999) In: Proceedings of the 27th Congress of European Brewers convention, Cannes, May 29–June 3
Avram D, Bakalinsky AT (1997) J Bacteriol 179:5971
Park H, Bakalinsky AT (2000) Yeast 16:881
Park H, Lopez NI, Bakalinsky AT (1999) Curr Genet 36:339
Rauhut D (1993) Yeast-production of sulfur compounds. Harwood, Reading
Tezuka H, Mori T, Okumura Y, Kitabatake K, Tsumara Y (1992) J Am Soc Brew Chem 50:130
Omura F, Shibano Y (1995) J Am Soc Brew Chem 53:58
Leemans C, Dupire S, Macron J-Y (1993) In: Proceedings of the 24th Congress of European Brewers convention, Oslo, June 8–10
Hansen J (1999) Appl Environ Microbiol 65:3915
Hansen J, Bruun SV, Bech LM, Gjermansen C (2002) FEMS Yeast Res 2:137
Wang ZX, Zhuge J, Fang H, Prior BA (2001) Biotechnol Adv 19:201
Overkamp KM, Bakker BM, Kotter P, Luttik MA, Van Dijken JP, Pronk JT (2002) Appl Environ Microbiol 68:2814
Cordier H, Mendes F, Vasconcelos I, Francois JM (2007) Metab Eng 9:364
Geertman JM, van Maris AJ, Van Dijken JP, Pronk JT (2006) Metab Eng 8:532
Remize F, Barnavon L, Dequin S (2001) Metab Eng 3:301
Remize F, Roustan JL, Sablayrolles JM, Barre P, Dequin S (1999) Appl Environ Microbiol 65:143
Michnick S, Roustan JL, Remize F, Barre P, Dequin S (1997) Yeast 13:783
Nevoigt E, Stahl U (1996) Yeast 12:1331
Cambon B, Monteil V, Remize F, Camarasa C, Dequin S (2006) Appl Environ Microbiol 72:4688
Eglinton JM, Heinrich AJ, Pollnitz AP, Langridge P, Henschke PA, De Barros Lopes M (2002) Yeast 19:295
Elbing K, Larsson C, Bill RM, Albers E, Snoep JL, Boles E, Hohmann S, Gustafsson L (2004) Appl Environ Microbiol 70:5323
Henricsson C, De Jesus Ferreira MC, Hedfalk K, Elbing K, Larsson C, Bill RM, Norbeck J, Hohmann S, Gustafsson L (2005) Appl Environ Microbiol 71:6185
Heux S, Sablayrolles JM, Cachon R, Dequin S (2006) Appl Environ Microbiol 72:5822
Gallander J (1977) Am J Enol Vitic 28:65
Volschenk H, Viljoen M, Grobler J, Petzold B, Bauer F, Subden R, Young R, Lonvaud A, Denayrolles M, van Vuuren H (1997) Nat Biotechnol 15:253
Ansanay V, Dequin S, Blondin B, Barre P (1993) FEBS Lett 332:74
Ansanay V, Dequin S, Camarasa C, Schaeffer V, Grivet JP, Blondin B, Salmon JM, Barre P (1996) Yeast 12:215
Denayrolles M, Aigle M, Lonvaud-Funel A (1995) FEMS Microbiol Lett 125:37
Williams SA, Hodges RA, Strike TL, Snow R, Kunkee RE (1984) Appl Environ Microbiol 47:288
Labarre C, Guzzo J, Cavin JF, Divies C (1996) Appl Environ Microbiol 62:1274
Husnik JI, Volschenk H, Bauer J, Colavizza D, Luo Z, van Vuuren HJ (2006) Metab Eng 8:315
Perez-Torrado R, Bruno-Barcena JM, Matallana E (2005) Appl Environ Microbiol 71:6831
Chen C, Wanduragala S, Becker DF, Dickman MB (2006) Appl Environ Microbiol 72:4001
Chen C, Dickman MB (2005) Proc Nat Acad Sci USA 102:3459
Terao Y, Nakamori S, Takagi H (2003) Appl Environ Microbiol 69:6527
Dowdy SF, Fasching CL, Araujo D, Lai KM, Livanos E, Weissman BE, Stanbridge EJ (1991) Science 254:293
Farmer AA, Loftus TM, Mills AA, Sato KY, Neill JD, Tron T, Yang M, Trumpower BL, Stanbridge EJ (1994) Hum Mol Genet 3:723
Nika J, Erickson FL, Hannig EM (1997) Yeast 13:1155
Izawa S, Ikeda K, Maeta K, Inoue Y (2004) Appl Microbiol Biotechnol 66:303
Izawa S, Sato M, Yokoigawa K, Inoue Y (2004) Appl Microbiol Biotechnol 66:108
Sekine T, Kawaguchi A, Hamano Y, Takagi H (2007) Appl Environ Microbiol 73:4011
Shima J, Sakata-Tsuda Y, Suzuki Y, Nakajima R, Watanabe H, Kawamoto S, Takano H (2003) Appl Environ Microbiol 69:715
Tanghe A, Van Dijck P, Dumortier F, Teunissen A, Hohmann S, Thevelein JM (2002) Appl Environ Microbiol 68:5981
Tanghe A, Van Dijck P, Colavizza D, Thevelein JM (2004) Appl Environ Microbiol 70:3377
Panadero J, Randez-Gil F, Prieto JA (2005) J Agric Food Chem 53:9966
Rodriguez-Vargas S, Sanchez-Garcia A, Martinez-Rivas JM, Prieto JA, Randez-Gil F (2007) Appl Environ Microbiol 73:110
Nielsen J, Jewett MC (2008) FEMS Yeast Res 8:122
Nielsen J, Penttila M (2008) FEMS Yeast Res 8:119
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Donalies, U.E.B., Nguyen, H.T.T., Stahl, U., Nevoigt, E. (2008). Improvement of Saccharomyces Yeast Strains Used in Brewing, Wine Making and Baking. In: Stahl, U., Donalies, U.E., Nevoigt, E. (eds) Food Biotechnology. Advances in Biochemical Engineering/Biotechnology, vol 111. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2008_099
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