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Microsystems Technology and Biosensing

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First Online:
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 109)

Abstract

This review addresses the recent developments in miniaturized microsystems or lab-on-a-chip devices for biosensing of different biomolecules: DNA, proteins, small molecules, and cells, especially at the single-molecule and single-cell level. In order to sense these biomolecules with sensitivity we have fabricated chip devices with respect to the biomolecule to be analyzed. The details of the fabrication are also dealt with in this review. We mainly developed microarray and microfluidic chip devices for DNA, protein, and cell analyses. In addition, we have introduced the porous anodic alumina layer chip with nanometer scale and gold nanoparticles for label-free sensing of DNA and protein interactions. We also describe the use of microarray and microfluidic chip devices for cell-based assays and single-cell analysis in drug discovery research.

Keywords

Surface Plasmon Resonance Localize Surface Plasmon Reson Microsystems Technology Aqueous Compartment Bovine Serum Albu 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  1. 1.School of Materials ScienceJapan Advanced Institute of Science and TechnologyNomi City, Ishikawa, 923-1292Japan
  2. 2.Toyama New Industry OrganizationToyama City, Toyama, 930-0866Japan
  3. 3.Department of Applied Physics, Graduate School of EngineeringOsaka UniversitySuita City, Osaka, 565-0871Japan

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