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Fabrication of Three-Dimensional Tissues

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Tissue Engineering II

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 103))

Abstract

The goal of tissue engineering is to restore or replace the lost functions of diseased or damaged organs. Ideally, engineered tissues should provide nutrient transport, mechanical stability, coordination of multicellular processes, and a cellular microenvironment that promotes phenotypic stability. To achieve this goal, many engineered tissues require both macro- (∼cm) and micro- (∼ 100μm) scale architectural features. In recent years, techniques from the manufacturing world have been adapted to create scaffolds for tissue engineering with defined three-dimensional architectures at physiologically relevant length scales. This chapter reviews three-dimensional fabrication techniques for tissue engineering, including: acellular scaffolds, cellular assembly, and hybrid scaffold/cell constructs.

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Abbreviations

PLGA:

Poly(DL-lactic-co-glycolic) acid

PDMS:

Polymethylsiloxane

FDM:

Fused deposition molding

SLS:

Selective laser scintering

3-DP:

Three-dimensional printing

PAM:

Pressure-assisted microsyringe

PEG:

Poly(ethylene glycol)

CAD:

Computer-aided design

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Acknowledgments

We would like to thank the Whitaker Foundation (V.L.), American Association of University Women (V.L.), NIH NIDDK, NSF CAREER, David and Lucile Packard Foundation, and NASA for their generous support.

Author information

Authors and Affiliations

  1. Department of Bioengineering, University of California, 92093, San Diego, La Jolla, CA, USA

    Valerie Liu Tsang

  2. Harvard – MIT Division of Health Sciences & Technology / Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA

    Sangeeta N. Bhatia

  3. Brigham and Women's Hospital, 02115, Boston, MA, USA

    Sangeeta N. Bhatia

Authors
  1. Valerie Liu Tsang
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  2. Sangeeta N. Bhatia
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Corresponding author

Correspondence to Sangeeta N. Bhatia .

Editor information

Kyongbum Lee David Kaplan

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© 2005 Springer-Verlag Berlin Heidelberg

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Tsang, V.L., Bhatia, S.N. (2005). Fabrication of Three-Dimensional Tissues. In: Lee, K., Kaplan, D. (eds) Tissue Engineering II. Advances in Biochemical Engineering/Biotechnology, vol 103. Springer, Berlin, Heidelberg . https://doi.org/10.1007/10_010

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