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Gene Therapy and Gene Delivery Systems pp 169–191Cite as

Lentiviral Vectors

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Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 99))

Abstract

We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with integrated transgenes. Safety issues, including insertional mutagenesis and replication-competent retroviruses, are discussed. Innate cellular defenses against retroviruses and their implications for human gene therapy with different lentiviral vectors are also addressed.

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Acknowledgments

We thank Yasuhiro Ikeda for critically reviewing the manuscript. We apologize to those authors whose works were not cited in this selective review of more recent developments due to space limitations.

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  1. Molecular Medicine Program, Mayo Clinic College of Medicine, Guggenheim 18, 55905, Rochester, MN, USA

    Nils Loewen & Eric M. Poeschla

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Loewen, N., Poeschla, E.M. Lentiviral Vectors. In: Schaffer, D.V., Zhou, W. (eds) Gene Therapy and Gene Delivery Systems. Advances in Biochemical Engineering/Biotechnology, vol 99. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_007

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