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Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors

  • Julie H. Yu
  • David V. SchafferEmail author
Chapter
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 99)

Abstract

Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell exclusively, or stealthing the vector against nonspecific interactions with host cells and proteins. These approaches offer the potential advantages of enhanced therapeutic effects, reduced side effects, lowered dosages, and enhanced therapeutic economics. This review will discuss a variety of targeting strategies, both genetic and nongenetic, for re-engineering the tropism of two representative enveloped and nonenveloped viruses, murine retrovirus and adeno-associated virus. Basic advances in understanding the structural biology and virology of the parent viruses have aided rational design efforts to engineer novel properties into the viral attachment proteins. Furthermore, even in the absence of basic, mechanistic knowledge of viral function, high-throughput library and directed evolution approaches can yield significant improvements in vector function. These two complementary strategies offer the potential to gain enhanced molecular control over vector properties and overcome challenges in generating high titer, stealthy, retargeted vectors.

Adeno-associated virus Lentivirus Retrovirus Targeting Viral vector 

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Notes

Acknowledgments

The authors wish to thank James Koerber for a critical reading of this manuscript. J.Y. is supported by a Graduate Research Fellowship from the Whitaker Foundation. D.S. is supported by EB003007 and generous funding from the ALS Association.

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Authors and Affiliations

  1. 1.Department of Chemical Engineering and Helen Wills Neuroscience InstituteUniversity of CaliforniaBerkeleyUSA

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