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Noninvasive Imaging of Myocardial Ischemia pp 1–15Cite as

Principles of Pathophysiology Related to Noninvasive Cardiac Imaging

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8. Conclusions

The pathophysiology of myocardial ischemia involves a series of progressive changes from the cellular level through perfusion abnormalities, contractile dysfunction, electrocardiographic abnormalities, and finally symptoms. In clinical practice, it has multiple potential manifestations, with atherosclerotic coronary disease being the most important underlying etiology. Uncovering these abnormalities or their underlying causes requires selection of the most appropriate stress method depending on the question being asked, and the clinical status of the patient. A sound understanding of the principles of imaging will contribute to informed interpretation of test results. Only by integrating knowledge of the pathophysiology of myocardial ischemia, the role of the various stress modalities, and the strengths and weaknesses of the available imaging technologies will the best possible test be selected for each patient.

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Author information

Authors and Affiliations

  1. Queen’s University Belfast, Belfast, Northern Ireland

    Mark Harbinson MD, FRCP

  2. Royal Brompton Hospital, London, UK

    Constantinos D. Anagnostopoulos MD, PhD, FRCR, FESC

  3. Chelsea & Westminster Hospital, London, UK

    Constantinos D. Anagnostopoulos MD, PhD, FRCR, FESC

  4. Imperial College School of Medicine, London, UK

    Constantinos D. Anagnostopoulos MD, PhD, FRCR, FESC

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  1. Mark Harbinson MD, FRCP
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  2. Constantinos D. Anagnostopoulos MD, PhD, FRCR, FESC
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Editors and Affiliations

  1. Royal Brompton Hospital, London, UK

    Constantinos D Anagnostopoulos MD, PhD, FRCR, FESC

  2. Chelsea & Westminster Hospital, London, UK

    Constantinos D Anagnostopoulos MD, PhD, FRCR, FESC

  3. Imperial College School of Medicine, National Heart and Lung Institute, London, UK

    Constantinos D Anagnostopoulos MD, PhD, FRCR, FESC

  4. Hammersmith Hospital, Imperial College, London, UK

    Petros Nihoyannopoulos MD, FRCP, FACC, FESC

  5. Leiden University Medical Center, Leiden, The Netherlands

    Jeroen J. Bax MD, PhD  & Ernst van der Wall MD, FESC, FACC  & 

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Harbinson, M., Anagnostopoulos, C.D. (2006). Principles of Pathophysiology Related to Noninvasive Cardiac Imaging. In: Anagnostopoulos, C.D., Nihoyannopoulos, P., Bax, J.J., van der Wall, E. (eds) Noninvasive Imaging of Myocardial Ischemia. Springer, London. https://doi.org/10.1007/1-84628-156-3_1

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