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Cell Transplantation for Diseases of Myelin

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Stem Cell and Gene-Based Therapy

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Summary

Neural precursor cells that reside in the adult brain, a potential source of myelin-forming cells, do not produce effective remyelination in MS. The transplantation of exogenous cells, as an alternative source of remyelinating cells, has been pursued as a very active research area over the last decade and remarkable progress has been obtained. New sources of myelinating cells were characterized and different transplantation strategies have been proposed. Better understanding of the pros and cons of using each of the various remyelinating cell types, of the different routes of cell delivery, and of methods for cell tracking, form the basis for designing cell transplantation strategies in the clinic. Better understanding of the process of remyelination and insights into the mechanism of action of transplanted cells are still needed to optimize cell therapy in demyelinating diseases.

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Authors and Affiliations

  1. Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel

    Tamir Ben-Hur MD, PhD (Professor) & Ofira Einstein

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  1. Tamir Ben-Hur MD, PhD
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  2. Ofira Einstein
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© 2006 Springer-Verlag London Limited

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Ben-Hur, T., Einstein, O. (2006). Cell Transplantation for Diseases of Myelin. In: Stem Cell and Gene-Based Therapy. Springer, London. https://doi.org/10.1007/1-84628-142-3_6

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  • DOI: https://doi.org/10.1007/1-84628-142-3_6

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-979-1

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