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Basic to Clinical Cartilage Engineering: Past, Present, and Future Discussions

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Stem Cell and Gene-Based Therapy

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Conclusion

An analysis of the literature provides no evidence so far for regular regeneration of hyaline cartilage in animal experiments and still today’s treatments for cartilage resurfacing are less than satisfactory, and rarely restore full function or return the tissue to its native normal state. The rapidly growing field of tissue engineering holds great promise for the generation of functional cartilage tissue substitutes. Cell biologists, engineers, and surgeons work closely together with combined knowledge of using biocompatible, biomimetic, biomechanical suitable scaffolds seeded with chondrogenic cells and loaded with bioactive molecules that promote time-relapsed cellular differentiation and/or maturation.

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Author information

Authors and Affiliations

  1. Cartilage Research Unit, Göteborg University, Kungsbacka, Sweden

    Mats Brittberg MD, PhD, Tommi Tallheden & Anders H. Lindahl

  2. Department of Orthopaedics, Kungsbacka Hospital, Kungsbacka, Sweden

    Mats Brittberg MD, PhD, Tommi Tallheden & Anders H. Lindahl

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  1. Mats Brittberg MD, PhD
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  2. Tommi Tallheden
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  3. Anders H. Lindahl
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© 2006 Springer-Verlag London Limited

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Brittberg, M., Tallheden, T., Lindahl, A.H. (2006). Basic to Clinical Cartilage Engineering: Past, Present, and Future Discussions. In: Stem Cell and Gene-Based Therapy. Springer, London. https://doi.org/10.1007/1-84628-142-3_11

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  • DOI: https://doi.org/10.1007/1-84628-142-3_11

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-979-1

  • Online ISBN: 978-1-84628-142-6

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